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Bos taurus let-7c stem-loop (bta-let-7c) URS0000031E12_9913

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bta-let-7c: Bta-let-7c is a microRNA that has been observed in both placental exosomes and non-pregnant exosomes, with significant differences in expression compared to other bta-let-7 microRNAs [PMC5999645]. Overexpression of bta-let-7c has been shown to decrease the expression of NRAS and downregulate LPS-induced proinflammatory cytokines [PMC5999645]. Bta-let-7c, along with bta-let-7a-5p and bta-miR-196b, may regulate glycerophospholipid metabolism by inhibiting the expression of enzymes involved in triglyceride synthesis and degradation [PMC5341059]. Bta-miR-148a, bta-miR30a-5p, bta-miR30d, and bta-miR30d were found to be among the top 10 expressed miRNAs in different species of milk [PMC7191744]. Bta-miR127 and bta-let7c have been implicated in the regulation of inflammatory response [PMC4617749]. Bta-miR127 is known to regulate a specific gene along with btalet7c [PMC7937231]. Btale t 7c was found to be differentially expressed in CoPS vs. H comparison [PMC7937231]. In different tissues such as ovary and testis, several miRNAs including btamir143, btamir378, btale t 7f were found to be dominant expressed miRNAs with more than 100000 reads [PMC3164151]. In Holstein cattle several miRNAs including btamir143 were found to be most abundant [PMC5410099]. The role of target interleukin1 (IL1) may be affected by btamir181d and btale t 7c in regulating the mammary gland function of dairy cows [PMC9686552].

Genome locations

Gene Ontology annotations

Sequence

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GCAUCCGGGUUGAGGUAGUAGGUUGUAUGGUUUAGAGUUACACCCUGGGAGUUAACUGUACAACCUUCUAGCUUUCCUUGGAGC

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This sequence is found in 24 other species

Publications