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Gallus gallus (chicken) gga-miR-203a URS0000028BBC_9031

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gga-mir-203: gga-mir-203 is a microRNA that has been found to be significantly differently expressed in all three groups in a study [PMC5203650]. Its expression levels showed big changes in one group (CM) but small changes in another group (CS) [PMC5203650]. The study used qPCR to quantify the expression levels of gga-mir-203 and other miRNAs [PMC4123083]. The researchers also investigated the target relationship between gga-mir-203 and TP63 mRNA using a dual-luciferase reporter gene assay and found that gga-mir-203 can directly bind to the predicted target site of TP63 mRNA [PMC6157316]. TargetScan software predicted that TP63 mRNA is a direct target of gga-mir-203 and the predicted target site is highly conserved among vertebrates [PMC6157316]. The researchers also transfected a gga-mir-203 mimic into chicken primary myoblasts and found that it significantly downregulated the expression of TP63, suggesting that TP63 is a target gene of gga-mir-203 involved in myogenic differentiation [PMC6157316]. Another study identified gga-mir-203 as one of the miRNAs with significant differential abundance in two comparisons, suggesting its potential role in chicken skeletal muscle differentiation [PMC4256448]. Overall, these findings highlight the importance of gga-mir-203 in regulating gene expression and its potential role in myogenic differentiation.

gga-mir-203a: Gga-mir-203a is a microRNA that has been studied in relation to its role in viral replication and immune responses. The target genes of gga-mir-203a, such as TGM2, have been found to be involved in extracellular regions, vesicles, and exosomes, suggesting a potential role in miRNA exocytosis and membrane fusion-mediated interferon production [PMC5983721]. Additionally, gga-mir-203a has been found to be inversely correlated with STAT3 and IL-1R1 expression [PMC5983721]. In the context of NDV replication, gga-mir-203a has been shown to accelerate embryonic death and NDV replication [PMC5983721]. The expression of TGM2 is regulated by gga-mir-203a and plays a negative role in NDV infection [PMC5983721]. The overexpression of gga-mir-203a enhances NDV replication by suppressing TGM2 and deactivating the NF-κB signaling pathway [PMC5983721]. The relationship between gga-mir-203a and TGM2 has been validated through RT-qPCR and luciferase assays [PMC5983721]. In chicken embryos, NDV infection down-regulates the expression of gga-mir-203a, while its overexpression increases NDV replication both in vivo and in vitro by targeting TGM2 [PMC6718473]. Gga-mir-203a is also part of a complex interaction network with other miRNAs such as gga-miR-144-3p and genes involved in viral functions like TGFB2 [PMC5788541][PMC7086581].

Genome locations

Gene Ontology annotations


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This sequence is found in 31 other species

  1. Alligator mississippiensis Ami-Mir-203-v1_3p (mature (guide))
  2. Anolis carolinensis (green anole) aca-miR-203-3p
  3. Callorhinchus milii Cmi-Mir-203-P5-v1_3p (mature (guide))
  4. Chrysemys picta bellii (western painted turtle) Cpi-Mir-203-v1_3p (mature (guide))
  5. Cyprinus carpio (common carp) ccr-miR-203a
  6. Danio rerio dre-miR-203a-3p
  7. Gadus morhua gmo-miR-203a-3p
  8. Gekko japonicus Gja-Mir-203-v1_3p (mature (guide))
  9. Haplochromis burtoni abu-miR-203
  10. Latimeria chalumnae Lch-Mir-203_3p (mature (guide))
  11. Lepisosteus oculatus Loc-Mir-203-v1_3p (mature (guide))
  12. Maylandia zebra mze-miR-203
  13. Microcaecilia unicolor Mun-Mir-203-v1_3p (mature (guide))
  14. Monodelphis domestica (gray short-tailed opossum) mdo-miR-203
  15. Monopterus albus (swamp eel) Mal-Mir-203-P1-v1_3p (mature (guide))
  16. Neolamprologus brichardi (lyretail cichlid) nbr-miR-203
  17. Ophiophagus hannah oha-miR-203-3p
  18. Ornithorhynchus anatinus Oan-Mir-203-v1_3p (mature (guide))
  19. Oryzias latipes ola-miR-203
  20. Paralichthys olivaceus (Japanese flounder) pol-miR-203-3p
  21. Petromyzon marinus (sea lamprey) pma-miR-203b-3p
  22. Python bivittatus (Burmese python) pbv-miR-203-3p
  23. Salmo salar (Atlantic salmon) ssa-miR-203a-3p
  24. Scyliorhinus torazame (cloudy catshark) Sto-Mir-203-v1_3p (mature (guide))
  25. Sphenodon punctatus (tuatara) Spt-Mir-203_3p (mature (guide))
  26. Taeniopygia guttata tgu-miR-203-3p
  27. Takifugu rubripes fru-miR-203
  28. Tetraodon nigroviridis (spotted green pufferfish) tni-miR-203
  29. Tor tambroides miR-203a-3p
  30. Xenopus laevis (African clawed frog) xla-miR-203-3p
  31. Xenopus tropicalis (tropical clawed frog) xtr-miR-203