ssc-mir-338: Ssc-mir-338 is a microRNA that plays a role in inflammatory signaling and muscle development [PMC7333078] [PMC6737989]. The inhibition of ssc-mir-338 expression by lipopolysaccharide (LPS) was not affected by adrenocorticotropic hormone (ACTH) pretreatment, indicating that ACTH does not influence the LPS-induced inhibition of ssc-mir-338 [PMC7333078]. However, there was an ACTH × LPS effect on the expression level of ssc-mir-338, suggesting a potential interaction between ACTH and LPS in regulating ssc-mir-338 expression [PMC7333078]. The decrease in ssc-mir-338 level induced by LPS was not affected by ACTH pretreatment, suggesting that other inflammatory molecules may be targeted by the ACTH-stimulated miR-146 or ssc-mir-338 regulatory circuit [PMC7333078]. In a pig model, LPS injection alone significantly decreased the level of ssc-mir-338 [PMC7333078]. Additionally, four miRNAs, including ssc-miR-151-3p and ssc-miR-532-5p precursors, did not map to any chromosome in the available database but were paired with muscle-associated miRNAs such as ssc-miR133a3p and ssc-mir338 [PMC3579806] [PMC6737989]. These interaction pairs included several miRNAs known to have important roles in myogenesis [PMC6737989]. Overall, these findings suggest that ACTH pretreatment attenuates LPS-induced inflammation and mitochondria damage but does not affect the inhibition of sccmir338 or inducible nitric oxide synthase secretion induced by LPS [PMC7333078].
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