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Sus scrofa (pig) ssc-miR-338 URS00000254A6_9823

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ssc-mir-338: Ssc-mir-338 is a microRNA that plays a role in inflammatory signaling and muscle development [PMC7333078] [PMC6737989]. The inhibition of ssc-mir-338 expression by lipopolysaccharide (LPS) was not affected by adrenocorticotropic hormone (ACTH) pretreatment, indicating that ACTH does not influence the LPS-induced inhibition of ssc-mir-338 [PMC7333078]. However, there was an ACTH × LPS effect on the expression level of ssc-mir-338, suggesting a potential interaction between ACTH and LPS in regulating ssc-mir-338 expression [PMC7333078]. The decrease in ssc-mir-338 level induced by LPS was not affected by ACTH pretreatment, suggesting that other inflammatory molecules may be targeted by the ACTH-stimulated miR-146 or ssc-mir-338 regulatory circuit [PMC7333078]. In a pig model, LPS injection alone significantly decreased the level of ssc-mir-338 [PMC7333078]. Additionally, four miRNAs, including ssc-miR-151-3p and ssc-miR-532-5p precursors, did not map to any chromosome in the available database but were paired with muscle-associated miRNAs such as ssc-miR133a3p and ssc-mir338 [PMC3579806] [PMC6737989]. These interaction pairs included several miRNAs known to have important roles in myogenesis [PMC6737989]. Overall, these findings suggest that ACTH pretreatment attenuates LPS-induced inflammation and mitochondria damage but does not affect the inhibition of sccmir338 or inducible nitric oxide synthase secretion induced by LPS [PMC7333078].

Genome locations

Gene Ontology annotations


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This sequence is found in 26 other species

  1. Alligator mississippiensis ami-miR-338-3p
  2. Callorhinchus milii eshark_mir-338_1
  3. Cyprinus carpio ccr-miR-338
  4. Danio rerio dre-miR-338
  5. Equus caballus eca-miR-338-3p
  6. Gadus morhua (Atlantic cod) gmo-miR-338-3p
  7. Haplochromis burtoni (Burton's mouthbrooder) abu-miR-338
  8. Homo sapiens hsa-miR-338-3p
  9. Ictalurus punctatus (channel catfish) ipu-miR-338
  10. Macaca mulatta (Rhesus monkey) mml-miR-338-3p
  11. Maylandia zebra (zebra mbuna) mze-miR-338
  12. Mus musculus (house mouse) mmu-miR-338-3p
  13. Neolamprologus brichardi nbr-miR-338
  14. Oreochromis niloticus oni-miR-338
  15. Pan troglodytes (chimpanzee) ptr-miR-338
  16. Pongo pygmaeus (Bornean orangutan) ppy-miR-338-3p
  17. Pundamilia nyererei pny-miR-338
  18. Rattus norvegicus (Norway rat) Rattus_norvegicus piRNA piR-rno-63002
  19. Salmo salar ssa-miR-338a-3p
  20. Sarcophilus harrisii sha-miR-338
  21. Taeniopygia guttata (zebra finch) tgu-miR-338-3p
  22. Takifugu rubripes fru-miR-338
  23. Tetraodon nigroviridis (spotted green pufferfish) tni-miR-338
  24. Tor tambroides (Thai mahseer) miR-338
  25. Xenopus laevis xla-miR-338
  26. Xenopus tropicalis (tropical clawed frog) xtr-miR-338