ssc-let-7e: Ssc-let-7e is a microRNA (miRNA) that can be generated from miRNA-offset RNAs (moRNAs) [PMC4001129]. It has been found to be downregulated in chronic T. gondii infection, potentially targeting the TMEM173 gene and playing a role in the regulation of type I IFN-dependent innate immunity and inflammatory responses [PMC8851844]. Ssc-let-7e, along with other miRNAs such as ssc-miR-328, ssc-miR-128, ssc-miR-129a-3p, ssc-miR-28-3p, and ssc-miR-30c-3p, may also be involved in regulating the chemotaxis of immune cells [PMC8851844]. In Bama minipigs, the let-7 family of miRNAs including ssc-miR98 and ssc-let7e were found to be upregulated or downregulated in different contexts [PMC4489742]. In APC1311 pigs with early-stage colorectal neoplasia, several miRNAs including ssclet7e were associated with the disease [PMC5707088]. In more advanced HG-IEN samples compared to LG-IEN samples, levels of ssclet7e were significantly elevated [PMC5707088]. Ssclet7e was also one of ten differentially expressed miRNAs validated by qRTPCR in this study [PMC5707088]. Sscl et 7e is one of several small RNAs that can be generated from loops or regions between loops and stems [PMC4008308]. The let 7 family including sscl et 7a sscl et 7c sscl et 7d sscl et 7f sscl et 7g sscl et 7i and sscmir98 was found to be significantly differentially expressed in PRRSV-infected PAMs [PMC9550049]. Among conserved miRNAs, ssclet7a, ssclet7f, ssclet7c, ssclet7e, sscmiR103, sscmiR1403p, sscmiR199a3p and sscmiR199b3p had high read counts [PMC5815207].
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