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Homo sapiens (human) hsa-let-7e-5p URS000000B1C9_9606

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hsa-let-7e: Hsa-let-7e (MIMAT0000066) is one of the primers used in the study [PMC3821025]. The study found that DIM, a compound, can inhibit the expression of EZH2 in castration-resistant prostate cancer [PMC6222788]. This inhibition is achieved by up-regulating hsa-let-7e, which is ranked at 13th among the primers used [PMC6222788]. The up-regulation of hsa-let-7e by DIM leads to a decrease in EZH2 expression [PMC6222788]. This finding suggests that hsa-let-7e may play a role in regulating EZH2 expression in castration-resistant prostate cancer [PMC6222788]. Further research is needed to fully understand the mechanism by which hsa-let-7e regulates EZH2 and its potential therapeutic implications for castration-resistant prostate cancer [PMC6222788].

mRNA interactions 6 total

Genome locations

Gene Ontology annotations

Localisation

Sequence

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UGAGGUAGGAGGUUGUAUAGUU

Taxonomic tree

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This sequence is found in 22 other species

  1. Bos taurus Bta-Let-7-P1b_5p (mature (guide))
  2. Callithrix jacchus (white-tufted-ear marmoset) cja-let-7e
  3. Canis lupus familiaris (dog) cfa-let-7e
  4. Capra hircus chi-let-7e-5p
  5. Cavia porcellus cpo-let-7e-5p
  6. Cervus elaphus cel-let-7e
  7. Echinops telfairi (small Madagascar hedgehog) Ete-Let-7-P1b_5p (mature (guide))
  8. Equus caballus (horse) eca-let-7e
  9. Macaca mulatta mml-let-7e-5p
  10. Mus musculus (house mouse) mmu-let-7e-5p
  11. Nomascus leucogenys nle-let-7e
  12. Oryctolagus cuniculus Ocu-Let-7-P1b_5p (mature (guide))
  13. Otolemur garnettii oga-let-7e
  14. Pan paniscus ppa-let-7e
  15. Pan troglodytes ptr-let-7e
  16. Papio hamadryas (hamadryas baboon) pha-let-7e
  17. Pongo pygmaeus ppy-let-7e
  18. Pteropus alecto pal-let-7e-5p
  19. Rattus norvegicus (Norway rat) rno-let-7e-5p
  20. Saimiri boliviensis boliviensis (Bolivian squirrel monkey) sbo-let-7e
  21. Sus scrofa ssc-let-7e
  22. Tupaia chinensis (Chinese tree shrew) tch-let-7e-5p
Publications