mir143: MIR143 is a microRNA that plays a significant role in the regulation of various cellular processes, such as inflammation and apoptosis, particularly in the context of obesity [PMC9687157]. Studies have identified a negative correlation between the levels of MIR143 and the mRNA of pro-inflammatory cytokines like IL1β, IL6, and TNFα in the ovaries of obese individuals [PMC9687157]. This correlation suggests that MIR143 could be involved in the modulation of inflammatory responses that are associated with obesity [PMC9687157]. Moreover, the over-expression of MIR143 has been associated with a decrease in the expression of its predicted target proteins, which include hexokinase 2 (HK2) and the beta-1 adrenergic receptor (ADRB1) [PMC5735881]. These target proteins are known to be involved in metabolic pathways and the cellular response to stress [PMC5735881]. Additionally, an increase in MIR143 levels leads to a lower Bcl-2/Bax ratio, which is indicative of its potential impact on the mechanisms of apoptosis [PMC5735881]. Taken together, these findings suggest that MIR143 could have therapeutic relevance for the treatment of obesity-related inflammation and the metabolic disturbances that accompany it [PMC5735881; PMC9687157].