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Gallus gallus (chicken) gga-miR-15c-5p URS0000003D7D_9031

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gga-mir-15c: gga-mir-15c is a microRNA that was found to be downregulated during Avian Influenza Virus (AIV) infection [PMC7248314]. In a study examining the regulation of cDNMT3B, gga-mir-15c, along with other miRNAs (gga-miR-29b, gga-miR-383, and gga-miR-222), was of interest [PMC3086922]. The expression patterns of these miRNAs were investigated during meiotic stages of germ line development using qRT-PCR [PMC3086922]. The study found that gga-mir-15c, along with the other miRNAs, slightly decreased the expression of cDNMT3B 3′UTR eGFP [PMC3086922]. Furthermore, the expressions of gga-mir-15c, gga-miR-383 and gga-miR-222 were increased after E11.5 in males in correlation with cDNMT3B expression [PMC3086922]. The specific sequences for these miRNAs were obtained from miRDB database and their expressions were examined during germ line development using qRT-PCR [PMC3086922]. In addition to this, cDNMT3B 3′UTR mutants for each miRNA binding sites were generated and transfected into 293 FT cells to validate the downregulation of cDNMT3B at the post-transcriptional level [PMC3086922]. The study suggests that gga-mir-15c, along with gga-miR-383 and gga-miR222 may downregulate cDNMT3B in vivo during germ line development in both male and female chickens [PMC3086922]. Overall, this research provides insights into the regulation of cDNMT3B by gga-mir-15c and other miRNAs during germ line development [PMC3086922].

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Gene Ontology annotations


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This sequence is found in 13 other species