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ssc-mir-210: Ssc-mir-210 is a microRNA that participates in the regulation of the Neurotrophin signaling pathway by targeting corresponding genes such as BNDF, SHC4, KRAS, and FOXO3 [PMC4934789]. It is upregulated in renal cell carcinoma and is associated with the upregulation of EPAS1, EGLN3, EGLN1, and VEGFC [PMC4646468]. Ssc-mir-210 is induced by HIF1α under hypoxic conditions in mice [PMC4646468]. It has been shown to stabilize HIF1A and attenuate hypoxia-induced apoptosis, angiogenesis, and stress response in mammalian cells [PMC9674649]. Ssc-mir-210 has also been found to be differentially expressed after acute H-R stress in thalamus cells [PMC9674649]. It is mainly expressed in the liver, spleen, and stomach but also found in other tissues such as the brain and lungs [PMC3427155]. Ssc-mir-210 has been identified as a key miRNA involved in various biological processes [PMC8529057]. It is one of the most frequently expressed miRNAs across different samples [PMC6090871]. However, it was not among the miRNAs associated with PRRSV infections studied in a particular research project [PMC9651005]. Ssc-mir-210 plays a regulatory role in adipocytes along with other miRNAs such as ssc-miR-145-5p and novel-miR-126 [PMC8834144]. The expression differences of ssc-mir-210 have been validated using qRT-PCR along with other genes and miRNAs such as AGT, GK, CAT ssc-miR-874 ssc-miR-370 ssc-miR129b[ PMC8834144].
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