MIR663B: MIR663B is a down-regulated microRNA located in the intron of ANKDR30BL, and it is associated with various biological processes and diseases. In Immunity-H, genes such as SPRR3, CTGF, E2F5, MIR663B, and others have significantly higher mutation rates compared to Immunity-L [PMC9855412]. Previous studies have shown that silencing or knockout of POLRMT, a gene with higher mutation rates in Immunity-H, can inhibit cell proliferation and promote apoptosis [PMC9855412]. In patients with down-regulated MIR663B expression, there is a significant increase in the expression of genes associated with cell proliferation and migration [PMC7439310]. MIR663B has been found to regulate the expression of CCL17, CD40, and PIK3CD in chronic lymphocytic leukemia [PMC7439310]. Additionally, high expression of MIR663B is correlated with distant metastasis and advanced tumor grading in endometrial cancer patients [PMC5796233]. In endometrial cancer cells, PS suppresses MIR663B expression which plays an oncogenic role by upregulating pro-survival Bcl-2 and reducing apoptosis [PMC5796233]. The gene cluster on chromosome 2 contains an area between RNA5-8SP5 and MIR663B genes that includes Exp-MiBRs [PMC6792129]. Although there was no significant change in the expression of any miRNAs over time, there was a trend for an increase in MIR663B expression [PMC6416171].