MIR548AI: MIR548AI is a member of the miR548 family and has been identified as a potential regulator of gene expression in diabetic kidney disease (DKD) [PMC8183707]. In a study investigating the role of MIR548AI in endothelial cell (EC) and smooth muscle cell (SMC) dysfunction, it was found that MIR548AI was upregulated in SMC-derived exosomes in response to cytokine stimulation [PMC8553949]. The study also revealed that transfection with a MIR548AI inhibitor improved EC growth and mitigated SMC proliferation, suggesting that MIR548AI may be a potential target for protecting ECs [PMC8553949]. Furthermore, the study found that the MIR548AI inhibitor protected against cytokine-induced EC dysfunction, both in the presence and absence of SMC-derived exosomes [PMC8553949]. The functional impact of MIR548AI on ECs and SMCs was also observed, with the inhibitor attenuating both EC dysfunction and SMC proliferation [PMC8553949]. Additionally, it was noted that little is known about MIR548AI in the literature, particularly its role in the vascular system [PMC8553949]. The study concluded that targeting MIR548AI may have translational significance for interventions aimed at preventing EC dysfunction induced by exosomes from dysfunctional SMCs [PMC8553949].