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Homo sapiens (human) MAPT antisense RNA 1 (MAPT-AS1) URS000075DB76_9606

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mapt-as1: MAPT-AS1 is a long non-coding RNA (lncRNA) associated with the microtubule-associated protein tau (MAPT) gene, which has been implicated in the progression and prognosis of breast cancer (BC) [PMC9091000]. Studies have suggested that MAPT-AS1 may influence the sensitivity of breast cancer cells to paclitaxel, a chemotherapeutic agent, with its expression potentially affecting the drug resistance [PMC5799917]. Negative coefficients for MAPT-AS1 in prognostic models indicate that it may serve a protective role and be associated with a lower risk in clinical outcomes [PMC9478756]. However, its expression has been found to decrease in correlation with advanced Tau pathology and higher Braak stages, which is indicative of its involvement in neurodegenerative processes [PMC8774680]. In breast cancer specifically, reducing MAPT-AS1 expression has been shown to inhibit migration and proliferation of estrogen receptor-negative (ER-) breast cancer cells [PMC9389369], as well as decrease migration and invasion capabilities of certain BC cell lines [PMC5799917]. Furthermore, MAPT-AS1 may contribute to the stability of MAPT mRNA; overexpression can protect against mRNA degradation while knockdown can decrease mRNA stability [PMC7521548]. The interaction between MAPT-AS1 and DNA methyltransferase 1 (DNMT1) also suggests disease-specific effects on MAPT gene expression [PMC4919105].

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Gene Ontology annotations

Sequence

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GCGGCCGCCGAGUCCGUCCACAUCGCCAGGCCAGGAGUCAGAACAAGGACGGGCCUGUGAUGUGUCUGUCUAUGACGAGGAGGACAAUGUCCUAAGGAAUGGAGAGGAAGAAAGUGAAGGGAACCAGGUCCCUGGAUUCCAUGUGGAACAGUAGCCCAGGAUGUGCACUAUGGACUGUUACAAGAGAGAGACAUGAUCUUCCUUAAGGCAUUGAUUUGUCAUGAGUCUCUUUGUUAUAGCCACUUAACGUUACCUUAAUACACCCACUUCAUGGAUAAGUAAAACUGAGGCUUGGAGAAGCCCACAUUGACACAGCAAAGAAGGCUGGGGCUCUUGUGCUGGUUAAAUGGACCUUGAUGUCUUCCAAAUGUUUUCAUGCUGGAUUCUGAGCCACUCUCCUGGCUGCAACUCUGAGGCCGGGCAGACUUUCCGCUGGAAAGAGAACUCAAAUACUGGUGAGAGGUGGAUUUGAAGCCAGGAGCCCCAGGUUUUGGCUCUGCAGGUUUGCACCCAGCUCUGUGGUGUAUGCCCUCACAGGUCACCCAGGACCUCCUGUCCAGGCUUCUUCAGGCCACCCAUGAUGGAGUAGAUUUGAGGAAUGAGGUUUUCAAAGCAGUUAGUGUGCGGGAGAGUAACCCUGGGGCCUCCGGAACCAGAAGGGAGGGAUUUGGGGGCUGGAGCUUGGCAGUCCAGGUUCCAUUGUCCUCAUGUUCUCCCCACUGGCCUGGCCUGUCACUCCAGUCUCUGCAUAGGUUGUCACAUGGCAUUCUCCCUGUGUGUCUCUGUGUCUCUUCUCUUCUUUAUAAAGACAUAGUUAUAAUGGAUUAGGGCCCACCCUAAAAAAAAAAAAAAAAA

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