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Homo sapiens (human) microRNA hsa-mir-1 precursor (hsa-mir-1-1) URS000075CF56_9606

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MIR1-1: MIR1-1 is a type of miR1 in mammals that is mainly related to skeletal muscle development [PMC5424345]. In prostate cancer (PCa), miR-1 pretreatment was used to collect differentially expressed genes (DEGs), and the Gene Expression Omnibus (GEO) and ArrayExpress databases were searched with specific retrieval strategies [PMC6236292]. MIR1-1, along with other cardiac myomiRs, was found to be unperturbed in NKX2-5 knockout cardiomyocytes [PMC6828809]. The expression of MIR1-1, along with other myogenic miRNAs, was established during pluripotent stem cell differentiation into the cardiac lineage [PMC6828809]. MIR1-1 is a muscle-specific microRNA that is produced during the early stage of cardiogenesis [PMC7123062]. It has been implicated in the regulation of cardiac contraction and embryonic angiogenesis [PMC8624534]. SRF activates MIR1-1, along with miR133a, which regulates many mRNAs of MRTF-SRF target genes [PMC9185982]. MIR1-1 has been used as a target for mRNA co-delivery experiments in cardiomyocytes [PMC7832270]. It is embedded in the MIR1-1HG gene and promotes muscle differentiation and expression during myogenesis [PMC5137429]. In colorectal cancer (CRC), MIR1-1 and MIR133A2 had a copy number gain in approximately 7% of patients [PMC4967895]. The relative abundance of URA5 mRNA in samples with knockdown by miR1-1 was significantly lower compared to wild type samples [PMC3530498].

Genome locations

Gene Ontology annotations

Sequence

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UGGGAAACAUACUUCUUUAUAUGCCCAUAUGGACCUGCUAAGCUAUGGAAUGUAAAGAAGUAUGUAUCUCA

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This sequence is found in 14 other species

Publications