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MIR2278: The only available information about MIR2278 and cancer is that its upregulation is associated with the inhibition of leukemic cell proliferation and enhanced apoptosis [PMC7277136]. Interestingly, our miRNA candidates MIR2278, miR27b-5p and miR29b-1-5p have never before been documented in pancreatic cancer, as far as we know [PMC7277136]. Our bioinformatic analysis of miRNA array data now predict that sulforaphane, SF102, and SF134 affect NF-κB signaling by the induction of MIR2278, which is involved in the regulation of many NF-κB target genes [PMC7277136]. The top candidate was MIR2278, because it was predicted to regulate the highest number of NF-κB-related target genes, followed by miR27b-5p and miR29b-1-5p, which partially overlapped in regulation of NF-κB-related target genes [PMC7277136]. By this method, we identified MIR2278 as common and most significantly downregulated miRNA following sulforaphane, SF102, and SF134 treatment (Table S1) [PMC7277136]. In a separate study, it was observed that MIR2278 was one of the most upregulated microRNAs [PMC4215582].
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