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MIR98: MIR98 is a microRNA that has been implicated in breast cancer metastasis [PMC4653020]. In a study conducted on nude mice, MDA-MB-231 breast cancer cells infected with lentivirus carrying either MIR98 or a control (NC) were stimulated with CCL18, and their metastatic potential was evaluated [PMC4653020]. Among several microRNAs, including miR-18a, miR-21, miR-26a, miR-26b, miR-30b, MIR98 and miR-210, MIR98 was selected for further validation using Taqman quantitative RT-PCR [PMC3288043]. The study also found that when N-Ras is silenced in breast cancer cells, the ERK/PI3K/NFκB/Lin28b pathway is inactivated. This inactivation leads to the loss of Lin28b as an inhibitor of MIR98 and subsequently results in higher levels of MIR98. The increased levels of MIR98 further inhibit the expression of N-Ras [PMC4653020]. These findings suggest that reduction in MIR98 expression may contribute to enhanced breast cancer metastasis when stimulated by CCL18 [PMC4653020].
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