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MIR378D2: MIR378D2 is a type of microRNA that is expressed in most cell lines and ranks as the second highest in esophageal cell lines [PMC8697470]. It is part of the miR-378d family, which consists of two different chromosomes in humans, namely MIR378D1 and MIR378D2 [PMC8697470]. The target genes of LINC00665 and MIR378D2 are significantly enriched in the ubiquitin-dependent protein catabolic process, ubiquitin-protein ligase activity, and the neurotrophin signaling pathway [PMC6012059]. These target genes are mainly involved in regulating ubiquitin-dependent protein catabolism and response to calcium ion [PMC6012059]. In a study, RP4-684O24, RP11-283I3, and RP11-350G8 were found to coregulate 60 differentially expressed genes (DEGs), while LINC00665 and MIR378D2 coregulated 55 DEGs [PMC6012059]. These findings suggest that MIR378D2 plays a role in regulating protein catabolism and calcium ion response through its target genes.
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