MIR4443: MIR4443 is a highly expressed microRNA in non-SC-EVs [PMC9800941]. A systematic review and meta-analysis revealed that upregulated MIR4443 is associated with better prognosis [PMC7827149]. Bioinformatics analysis identified METTL3 as a target gene of MIR4443 [PMC9617873]. In a study assessing the normalization of miRNA expression, MIR4443 was one of the miRNAs analyzed [PMC7035418]. However, the specificity of MIR4443 to Graves' disease was not investigated in patients with other autoimmune diseases [PMC5671953]. Additionally, MIR4443 has been found to inhibit cisplatin-induced ferroptosis by regulating AIFM2 expression in an m6A-dependent manner through METTL3 [PMC8572460]. In summary, MIR4443 is a highly expressed microRNA that has been associated with better prognosis and identified as a target gene for METTL3. It has also been analyzed in the context of miRNA normalization and its specificity to Graves' disease. Furthermore, its role in inhibiting cisplatin-induced ferroptosis has been elucidated.
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