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Homo sapiens (human) Prader Willi/Angelman region RNA 5 (PWAR5) URS000075990E_9606

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PWAR5: PWAR5, also known as PAR5, is a long non-coding RNA (lncRNA) that has been implicated in various types of cancers, including glioma, anaplastic thyroid carcinoma (ATC), and pancreatic ductal adenocarcinoma (PDAC) [PMC7944284] [PMC6183593] [PMC7721101]. In a study investigating the lncRNA-miRNA-mRNA network in glioma, PWAR5 was found to be negatively correlated with hsa-miR-144-3p and hsa-miR-381-3p [PMC9336119]. Furthermore, PWAR5 was shown to regulate the proliferation and progression of glioma by binding to EZH2 [PMC6183593]. In another study on papillary thyroid carcinoma (PTC), PWAR5 was identified as an independent prognostic signature and found to be downregulated in PTC tissues compared to normal tissues [PMC6183593]. Additionally, the expression level of PWAR5 was found to be different between PTC tissues and normal tissues in multiple datasets [PMC6183593]. In a study on vestibular schwannoma (VS) cells exposed to electromagnetic fields (EMF), PWAR5 was downregulated following chronic EMF exposure [PMC8307028]. Furthermore, in a study on kidney renal clear cell carcinoma (KIRC), overexpression of PWAR5 was associated with a better prognosis in KIRC patients [PMC9536954]. Overall, these findings suggest that PWAR5 may play important roles in cancer development and progression.

Genome locations

Gene Ontology annotations

Sequence

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UUUCCUUCAUGUAGAUUGCUGUGUGUGUCUUUUUCUUCAUAAUUCCCCUUAAUUCUGUGUGCUUUGAAUGACACUGUUGUUGUUACUGUUGUUUUAUAUCCAUUGUCACAUAAAACUCUUAUCAUUUAUUCUUCCAGGCCAGGGACUGUCCUUAUGGGUAGAGAUACACUAUCUGCAGGAAUUUAUUUUUUUACGUAUUUUUACUAGUUGAUGGGAAAGACAUUGGGAAAGACCUGGGCUGGAUUUGUGAUGAGCUGUGUUUACUGAGCAUGAUGAAGUAAAGCUCAACGUGAUUACUCUGAAGUCCAGCCUUACUGUCAGUCUAAGGACUCAGGAUACAAAUACUCAAAACAUAAAUUCUUAGACUCUAAAUUUCACAUGGUUUUUCCUAUCAGUACAGGUUAAGGAUAAUGGCGUGUUGUAGGUUUUUCCAGUGCAAUACAAGGAAGUUGGUUCUAGAUCCUUUAGUACAGUUAAUGUUUUGUAGAGUGUGUUCUAUGUUCACUGCAUUGGUAUGUCUCAUCUUUGGCAUGAUCUUGGCUCACCGCAACCUCCGCCUCUUGCAUUCAAGCACUUCUUGUCUCAGCCUCCAGAGUAGCUGGGAUUACAAGCAUGUGCCAACAUGCCCGGCUAAUUUUUGUAUGCUUUUGUGGAGACAGGCUUUGCCAUGUUUGCCAGGUUGGUCUCUAAGUGAUCCACCCGCCUCAGCCCCACAAAGUGCUGGGAUUACAUGCGUGAGCCACCGUACCCAGCCACACCUUUGCUUAUUUCUACUAUGCAUUUCAAGUGAUCAUUUCAAGAGAAUAAGUACUUAGGAGCUCCUAUGCUCUUUUUUUUUUUAACCCUGUUGCUUGCAUCACCCGGUUCCAACCCUAUAUGAAAGUUUCAUGAGCAUGUUUCUGUCACUGAGGCAGCUUCUCCAUUUGGCAUAUAAUUGAGAAAUUGCUAGUUUGUGGCUGAGACAUUGGUUUGAGAGGAGACGUAAUUUAUAUAUUUAGCAGAAUGCUUAAGUUACAUUUCCAGAGAUUAAUUUAAUUCUACUUUUAAUUAAGUUAACCCUUUGCUGUAUCUUUACAAGACGUAGGUGGAGAUUUAAUUUUGACUCUUAGAUUCAGUUAAGGUGAUGAAAUUGGCAUUAUAUAGUUUUUGAUGCUGAGCCCCACGGAGAUUAAAAGAUUUGCUAAACACCAUGCAAUUUUUGAAUCACAUCUCUAAUCUCACAUUAUUCUGUACUCUAUUUUUUGCUUGUAUGAUUGAUGGGUCUUUCAUUAUCUGUGAUUGACAUUCUAUGAGUAGGUGCUUUUGCUUUGCCUAUAAGUCGUUAUUAUGAAGGAGGAAUGGUGAAUAAGAAGGUAAUUUAGAAAAGCCUAUAUUAAAUAUACCAUGAACAUUGAAUAUAGCAAGAUCUUAUUCUCUAGUUGUUAUCUUAGUUGAUAAAUUCUGUAUGUGUUAUGUGUUUGUGUAUACAUAUGUACAUAUUAAUGAUGUGGGUGUUGAUACUGUGAUCACAUGACAAAUGACUGGUUUAUAGUGAAAAGCUGUUGGGGUUCAGAGAAAUGAACAUUCUUCUAAAAGUGAGGUAGAUAAGUUAUUUUAUAGUUCUUGCCUUUGAGUCUCUGUUCUUCUGGUAGAAAUGUUAGUGUAUUUAUAACCUCUCAGAUUUGUUUGGUUCUCUUAGUGUUCUUGAUCCAGGCAGUUAGCGAUAUGUUGGAUGAAUUGAGAAAAAUGAGUUUUUCCUUUCCUACUAACUGAAUUAGAUUAGAAAUAAGCAGUUAAGUGAGAAAAAUAGGGAAUUAGUGCCAGAUAUGUUGAGGUGUAGUGUUGACAGGGGGUCUUUUACCUUCAGAUGUUUGGUGCAACUUAGAGAAUGCAGUGGUAGUUGCUGGCCCAGCCCAUCCAAACAACCUCAUUUGUGGGGUGAUACUUCACAGAUGACUUAAAAUAAAUCCCCUGAAAAUAAGAAUCUCUGGAAGAGAUGACACGUGUAUGUGCGUGUGUGCACGUGUGUGCGUGUGUGCACGUGUGUGUGUGUGUGUGUUUUGGUGGAGUGGUAGGAGGAGGGUUGGCUUAAUGAUGAGAAUCAUUAUUUCUUGAAUUGGAUGACACUUUCCAUUCCUGCAAAGGGAGCGUGAGGUCCAGCCUUGCUAAUUCAUGAUCAAAGUAAUUUGCUGAGAGUAGUGGAAGGAAUGAGUUAGCAGAAGAUGGCAAAUUGCAUUAAUGAGUAGUAGGAGGAAAACAAAUAAGCAAAUUUUAAUGUGGUUGGAACAUGUUCCUGAGUUGUAUGAAGGGAGACAGGUAAAUUGAGAGUAAUGUUAUGAUUGUUUCAUUUGUUGGAAAUAAGGAAAACUUGCAUGGUUUGAAUUGUGGAACAAUAGGUGGUGUAUGUUAGGAGUCAGAAUUAUCAUUUAACAUGUAAGUUUCUGUUUUACUUCAGAUAAAGAAUGUCAGCUACCUUUCCCAUGUUAGCUUCUAUACCUUUUCUUGAGGUGACCAUAAAUAGGUAAUAUUGUCUUUCACUGAGAUUGUUUUAAUUAGCGAAGUGUGCUGAUUAAAUGUCUUUUCUUGAUAAAUUAUUAGAAUGAAUAAAGGAUGGUAUUUCUAGAUAGCCUUGGUUAGUCAGUGAUUUGUUUAAAUUUAGUGUGGAUAAGAAUCACCUGAGGGCUUUUUAAACACAGUUUACUGGGUCCUGACCUUAGUGUUUCUGGCUUAUUAGGUAUAAGUAUGAGAAGUUGAUUUUUAUCAAGUUUCUAGAUGCUACAGAUCUAGGAACCAUACUUAGAGUGCUAUUAUAUGUCUUUUAAUGUACACUGAUAUGGAAAAAGCAAUGAUACAUCAUGUUAUCGCAUAUUUUAAAAUGUGAUCAUGACCAGGGAAUCUUGAAAGUUGUCUUAUGUAAUAAUGUAAAUCAAUGUAGAAUACCAUAUAUUUUUUUCUUGCAAGGUUAUUAUUAAUAGGAAUGACUAUUUGUAGCCAAUGUGUUCAAAUGCAUGGGAGGACGUAAACACUUCAUAAUUUCCUGGAAAUACAGACAUAUAUCACUUAAAAUAAUACAUUUCUAAUAUAAAUUUAAAUUAUCUACGUGAUAUGAGGAAACGAGCUUAUUUUUGAUAAUUUUCCUAGCAGUGAAUCAACUAUACUCAUUUGAAUCUAAAUUAAAUUAAAUUUGAGUAAAUUCAGCCAUUUCUAAAUUCAGUCCAUAUAAAUUCACUUUGGGUAAAAGAAGACAAAAUUCCUGAAAACAGUAGAUUAAAAAAAUAACAUUUUAAGAGCAGGUAUGAUCUCAAUGAAUAUAGUGUGGUAAUUUCUGCCUAAUACCUACCCUUUUGGAGGAAGGAAAGGUAAUCCUGUUUGUGUUUAAUGUUAAUUACUGAAC

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Publications