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Homo sapiens (human) microRNA hsa-mir-944 precursor URS0000663F9C_9606

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MIR944: MIR944 is a microRNA that has been studied in various contexts. It has been found to be overexpressed in patients with non-small cell lung cancer (NSCLC) [PMC5627048]. MIR944 has also been shown to modulate sensitivity to chemotherapy in other solid tumors [PMC8602334]. The MIR944 promoter is regulated by the transcription factor ΔNp63, which binds to the promoter region and activates transcription [PMC4551945]. The binding of ΔNp63 to the MIR944 promoter is reinforced by the co-regulator AP-2 [PMC4551945]. The chromatin structure of the MIR944 promoter region is relatively open in keratinocytes, which allows for transcription initiation [PMC4551945]. Conservation analyses have shown that MIR944 is a relatively young gene in evolutionary terms, with conservation limited to primates [PMC4551945]. TFAP2A and TFAP2C have been identified as co-regulators that bind to the MIR944 promoter and enhance ΔNp63-mediated activation of transcription [PMC4551945]. The activity of the MIR944 promoter is dependent on ΔNp63 expression, but not linearly dependent on its quantity [PMC4551945]. Overall, these findings suggest that MIR944 has its own independent promoter and its expression is regulated by ΔNp63 and co-regulators such as AP-2, TFAP2A, and TFAP2C.

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This sequence is found in 1 other species