bta-mir-484: Bta-mir-484 is a miRNA that has been found to have various roles and associations in different biological processes. It has been identified to have a complementary site in the 3'UTR of the STAT5 mRNA and is also paired with the 3'UTR of the HK2 mRNA with five other miRNAs [PMC3551688]. Bta-mir-484 has been observed to have a negative correlation with QDPR, LY6E, and DOLPP1 genes, as well as a positive correlation with C16:0 concentrations in milk [PMC6164576]. It functions as a tumor suppressor and may serve as a prospective biomarker for cervical cancer by targeting ZEB1 and SMAD2 genes [PMC6164576]. Bta-mir-484 is also important in the regulation of lactation signaling [PMC6164576]. In Chinese Holstein cattle, a SNP in bta-mir-484 disrupted miRNA binding, leading to increased expression of the target gene heat-shock transcription factor 1 [PMC3478155]. Bta-mir-484 has been experimentally verified as a miRNA gene in bovine [PMC2254598]. It is predicted to target CASP3 gene, which is associated with inflammatory response [PMC8433134]. Several sub-networks involving bta-mir-484 have been identified as potential pathways/genes that may contribute to bovine endometritis progression and could be regarded as biomarkers and therapeutic targets for this infection [PMC8433134]. The SNP G4693T affects HSF1 gene expression by influencing the binding of HSF1 to bta-mir-484 [PMC9659462]. Mutations in bta-mir-484 seed sequence neo-SNPs (G4693T) directly lead to increased expression of HSF1 while affecting heat stress resistance response in cows [PMC8959652].