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MIR20A: MIR20A is a type of microRNA that is involved in mediating MYC and STAT3 dosage compensation through a redundant mechanism [PMC8627999]. In a study investigating regenerative therapy for jawbone atrophy, an atelocollagen-based gene-activated matrix (GAM) containing naked-pDNAs encoding MIR20A was used [PMC7955717]. The expression of MIR20A, along with other microRNAs, was assessed using RT-PCR and shown in Figure 4 [PMC9687337]. SNHG5, an upregulated gene, was found to reduce MIR20A expression and increase the expression of apoptosis proteins BECN1, ATG5, and ATG7 [PMC6912041]. Additionally, SNHG5 could interact with MIR32 to reduce the migration and proliferation effects of SNHG5 on gastric cancer cells [PMC6912041]. In a preliminary experiment using cultured MSCs, it was found that the delivery of MIR20A using an atelocollagen-based GAM had high transfection efficacy without cytotoxicity compared to commercial vectors such as a lentiviral vector [PMC7955717].
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