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MIR29A: MIR29A is a microRNA that is involved in various biological processes and diseases. It is a type of non-coding RNA that regulates gene expression. One study found that MIR29A, along with miR24, is primed by myocardin and plays a role in atherosclerosis retardation and matrix remodeling and fibrosis [PMC7123062]. In patients with non-small cell lung cancer (NSCLC), MIR29A levels were significantly lower compared to patients with small cell lung cancer (SCLC) [PMC9987486]. Additionally, MIR29A was found to be differentially expressed in pancreatic ductal (PD) compared to viral pancreatitis (VP) specimens, along with miR-23a and miR181c [PMC8407885]. The expression of MIR29A was also associated with patient prognosis, where elevated expression of certain microRNAs including MIR29A was correlated with poor patient survival [PMC6368411]. In liver fibrosis, TGF-β1 was found to downregulate MIR29A, potentially inducing the expression of Fstl1 [PMC7493388]. Furthermore, MIR29A has been found to be upregulated in breast cancer stem cells (BCSCs), aggressive breast cancer cell lines, and breast cancer tissues [PMC9102147]. Finally, the importance of MIR29A during the regression of liver fibrosis has been highlighted in a study [PMC6412626]. Overall, these findings demonstrate the diverse roles of MIR29A in various diseases and biological processes.
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