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sly-miR396a-5p: Sly-mir396a-5p is a circular RNA (circRNA) that has been identified as a potential salt-responsive circRNA and functions as a miRNA sponge by binding to sly-mir396a-5p and sly-miR396b, which in turn regulate the expression of Solyc04g025530.3 (glutamate decarboxylase 4) [PMC8625345]. Additionally, sly-mir396a-5p and sly-miR396b have been found to be down-regulated in the drought-tolerant genotype IL9-1, while they are up-regulated in the sensitive genotype M82 after drought stress [PMC5485680]. These miRNAs, including sly-mir396a-5p, show differential expression between the two genotypes [PMC5485680]. Sly-mir396a-5p has been identified as targeting GRF3, GRF4, and GRF8 genes [PMC7060562]. Furthermore, sly-mir396a-5p is among several miRNAs that regulate abiotic stress tolerance in tomato by targeting members of the SlHVA22 gene family [PMC9602767]. Additionally, it has been found that several tomato miRNAs including sly-mir396a-5p are involved in the development and stress response of tomato by targeting PLATZ genes [PMC9697139]. Specifically, sly-mir396a-5p and sly-miR396b have been implicated in drought stress response in tomato [PMC9697139].
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