mmu-mir-106b: Mmu-mir-106b is a microRNA that has been found to be differentially expressed in plasma and aorta tissue samples [PMC4346489]. It is part of the miR-106b~25 cluster and is located in the 13th intron of the MCM7 gene [PMC7803573]. In a study comparing atherosclerotic tissue with control tissue, mmu-mir-106b was found to be downregulated [PMC4346489]. Additionally, in another study, mmu-mir-106b was downregulated in DIO mice [PMC4571067]. The regulation of mmu-mir-106b may occur at the transcriptional level through activation of the ER stress effector pathway PERK [PMC7803573]. Computational prediction suggests that mmu-mir-106b may have more unpaired bases than other miRNAs, indicating that Dicer can tolerate loosely paired structures [PMC5716067]. Mmu-mir-106b has been found to be regulated by transcription factors Esrrb and Oct4, Sox2, Nanog, and Esrrb (OSNE) [PMC9149258]. It has also been shown that mmu-mir-106b can regulate more than 10 target genes [PMC9149258]. In an experimental study using AAV9 vectors, mmu-mir-106b precursor miRNA was expressed in neonatal mice through intraperitoneal injection [PMC8355162]. References: [PMC4346489] [PMC4571067] [PMC7803573] [PMC5716067] [PMC9149258] [PM8355162]