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bta-mir-193a: Bta-mir-193a is a differentially expressed (DE) microRNA (miRNA) in bovine mammary epithelial cells stimulated with S. uberis in vitro [PMC4065264]. It is generated from bta-mir-193a-2 and is reversely complementary to bta-mir-193a-3p [PMC4029070]. Bta-mir-193a, along with other miRNAs such as bta-miR-200c, bta-miR-210, and let-7e, has been identified as DE in response to S. uberis and LPS in other species [PMC3589390]. It has been found to be down-regulated at 4 hours post-infection (hpi) [PMC3589390]. Bta-mir-193a has been identified as a drug target for bovine disease and a potential regulatory marker for bovine trypanosomosis diagnosis and treatment [PMC6722470]. It is highly conserved across different species ranging from human to zebra [PMC6722470]. Bta-mir-193a has been shown to regulate the expression of proinflammatory cytokines, promote apoptosis, inhibit bacteria, and be involved in Toll-like receptor signaling during trypanosomosis infection [PMC6722470]. It is also significantly involved in gene silencing and RNA-induced silencing complex processes [PMC6722470]. In the context of host-virus interaction, bta-miR-29b and bta-mir-193a have been found to be down-regulated upon CPIV3 infection and likely participate in MDBK cells' response to the virus [PMC5885596]. However, the expression levels of bta-miR-2333 and other miRNAs close to bta-mir-193a were not significantly overexpressed in cultured myoblast cells transfected with the expression vector OPmiR-365-3p [PMC7802253].
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