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hsa-mir-4762: Hsa-mir-4762 is one of the four miRNA genes identified in the study that contains polymorphisms overlapping both the Drosha and Dicer cleavage site [PMC4299713]. A prognostic prediction model of 4-miRNA expression signatures, including hsa-mir-4762, was established using the Cox risk proportional regression model [PMC8797695]. Hsa-miR-190b, hsa-miR-3170, hsa-mir-4762, and hsa-miR-18a were found to be highly expressed in high-risk patients, particularly hsa-miR-18a [PMC8797695]. These four miRNAs were identified as independent prognostic indicators of sarcoma [PMC8797695]. Hsa-mir-4762 was found to target the RUNX1 gene along with hsa-miR-18a [PMC8797695]. No previous reports on hsa-miR-190b and hsa-mir-4762 in tumor research have been found [PMC8797695]. Hsa-miR-18a, hsa-miR3170, hsa-mir-4762, and hsa-miR-190b were enriched in sarcoma tissue samples and played important roles in cancer prognosis [PMC8797695]. The expression of hsa-miR-190b, hsa-miR-3170, and hsa-mir-4762 was higher in low-risk patients [PMC8797695]. The four identified miRNAs were found to have target genes that were filtered as degradation targets based on their interactions with other genes [PMC8797695].
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