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MIR7-1: MIR7-1 is a microRNA precursor that is generated from HNRNPK intron 15 [PMC4647676]. Further research is needed to understand the genetic regulation and expression of MIR7-1, as well as its role in metabolic traits [PMC9522793]. MIR7-1 is located in the last intron of the HNRNPK gene, and its expression is driven by the promoter of HNRNPK [PMC9522793]. The transcription factor FOXP3 positively regulates miR-7 expression in breast cancer [PMC4600152]. miR-7 can be expressed from three loci in humans, including MIR7-1 [PMC4600152]. The exact mechanism of miR-7 stimulation via the PI3K/Akt pathway is still unknown, but c-Myc has been found to directly bind and stimulate expression from the MIR7-1 promoter [PMC4600152]. Other transcription factors, such as HOXD10 and HNF4α, have also been involved in promoting miR-7 expression via interaction with the promoter regions of miR-7 genes including MIR7-1 [PMC4600152]. MIR7-1 is believed to be the most highly expressed source of mature miR-7 and is located within the hnRNPK gene on chromosome 9 [PMC4600152]. In addition to its role in breast cancer, MIR7-1 has also been implicated in other diseases such as neurodegenerative alterations and metabolic alterations [PMC9571148].
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