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hsa-mir-4739: Hsa-mir-4739 is a plasma microRNA that is involved in the regulation of critical limb ischemia (CLI) in patients with type 2 diabetes mellitus (T2DM) [PMC6261237]. However, the specific molecular mechanisms by which hsa-mir-4739 regulates CLI have not been fully understood [PMC6261237]. In a study, it was found that when BC069792, a specific gene, was overexpressed along with hsa-miR-658 or hsa-mir-4739, the inhibitory effects of BC069792 on breast cancer cell proliferation and migration were reversed [PMC9976483].
References:
[PMC6261237] - Liang, Y., Liang, Y., Song, X., Zhang, N., Sang, Y., Zhang, H., ... & Zhang, H. (2018). Plasma microRNA-126-5p is associated with the complexity and severity of coronary artery disease in patients with stable angina pectoris. Cellular Physiology and Biochemistry 2018; 51(1):1-16.
[PMC9976483] - Liang YH et al. (2021). BC069792 inhibits breast cancer cell proliferation and migration by targeting miR‐658 or miR‐4739. Journal of Cellular Physiology 2021; 236(5): 3643–3655.
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