hsa-mir-449c: Hsa-mir-449c is a microRNA that has been identified as one of the top 10 upregulated miRNAs in ChiPS [PMC6770352]. It has been shown to positively cis-regulate the expression of ZNF141, DHX29, NOC2L, MAS1L, and AFAP1L1 [PMC8810098]. Additionally, hsa-mir-449c has been found to be one of the 14 miRNAs involved in the regulation of pathways related to HER2 BC [PMC5123339]. In gastric tumors, hsa-mir-449c expression is decreased and it has been shown to induce senescence and apoptosis through activation of the p53 pathway [PMC5123339]. Hsa-mir-449c is also found to be up-regulated in omental metastases [PMC5945511]. It has been reported that hsa-mir-449c expression is significantly correlated with sperm count, progressive motility, and normal morphology [PMC7851476]. Hsa-mir-449c belongs to the miR-449 family which also includes hsa-miR-449a and hsa-miR-449b [PMC7851476]. Methylation of the hsa-miR-449abc promoter region is negatively correlated with expression ratio of hsa-miR-449a, hsa-miR-449b, and hsa-mir-449c [PMC7851476]. In oligoasthenoterathospermia patients, there is a significant downregulation of hsa-mir-449c compared to fertile individuals [PMC7851476]. Hsa-mir-449c, hsa-mir-149, and hsa-mir-2116 have similar expression patterns in both treatment groups [PMC6433273].