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bmo-mir-2763: Bmo-mir-2763 is a novel microRNA that is specifically expressed in the pupal stage of the silkworm. It has been found to regulate diapause initiation through diapause hormone receptors [PMC5507411]. In the silkworm genome, three potential targets have been identified for bmo-mir-2763, including diapause hormone receptor-4 and nuclear receptor GRF [PMC4640560] [PMC2824724]. The expression of bmo-mir-2763 in the pupal stage is consistent with the detection of GATA-beta 3, a protein involved in choriogenesis, in pupae but not in larval tissues [PMC2824724]. Bmo-mir-2763 is predicted to target BmGATA beta isoform 3, which regulates the expression of chorion genes during late stages of choriogenesis [PMC2824724]. In larvae, bmo-mir-2763 and another novel microRNA, bmo-mir-3001, are present at low levels compared to other stages. However, in the moth stage, three novel microRNAs including bmo-miR-2998 and bmo-miR-2999 are most abundantly expressed [PMC2824724]. These findings suggest that bmo-mir-2763 plays a role in regulating developmental processes such as diapause initiation and choriogenesis during different stages of silkworm development.
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