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hsa-mir-379: Hsa-mir-379 is a microRNA that targets the 3′-UTR of Lamp2a, a protein involved in the degradation of α-Syn, a protein associated with the accumulation of α-Syn in neurodegenerative diseases [PMC7698349]. Downregulation of Hsp70 or Lamp2a leads to the accumulation of α-Syn, and several microRNAs have been identified to target the 3′-UTR of Hsp70 or Lamp2a, including hsa-miR-26b, hsa-miR-106a, hsa-miR-301b [PMC7698349]. Interestingly, hsa-mir-379 is also identified as a microRNA that targets the 3′-UTR of Lamp2a [PMC7698349]. Although not considered a top candidate, hsa-miR-1207-5p has been found to have a target site near hsa-mir-379 [PMC3271095]. This proximity suggests that hsa-miR-1207-5p may also play a role in regulating Lamp2a and potentially contribute to the accumulation of α-Syn [PMC3271095]. Further research is needed to fully understand the role and significance of these microRNAs in neurodegenerative diseases and their potential as therapeutic targets.
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