hsa-mir-296: Hsa-mir-296 is a differentially expressed miRNA that has been studied in various contexts [PMC3110257]. It has been found to be downregulated in psoriatic uninvolved skin compared to normal skin [PMC3110257]. In a study on group A, hsa-mir-296 was also found to be downregulated, while several other miRNAs were upregulated [PMC4453619]. Hsa-mir-296 has been identified as one of the downregulated miRNAs in different studies, including those focused on hepatitis C viral replication and angiogenesis [PMC9953690] [PMC7565861] [PMC2887814]. It has also been shown to play a regulatory role in angiogenesis and is influenced by angiogenic factors [PMC2887814]. Hsa-mir-296 is known to target the VEGFA gene and is involved in the VEGF signaling pathway [PMC7955132]. It has also been found to be associated with TMED2/3/4/9 and other related miRNAs in an interaction network analysis [PMC9816852]. The expression levels of hsa-mir-296 have been analyzed using qRT-PCR assays with specific primers and probes [PMC3917617] [PMC4113354]. Inhibition of hsa-mir-296 with antagomirs has shown promising results in reducing angiogenesis in tumor xenografts in vivo [PMC2887814].
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