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Mus musculus (house mouse) mmu-miR-23b-3p URS0000183BED_10090

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mmu-mir-23b: Mmu-mir-23b is a microRNA that plays a role in various biological processes. It is involved in the differentiation of primordial germ cells by regulating the Lin28 and Blimp1 genes [PMC9505168]. Mmu-mir-23b is also identified as a differentially expressed microRNA (DEmiRNA) in both neural stem/progenitor cell (NSPC)-induced endothelial cell (EC) alteration and EC-induced NSPC alteration [PMC7758130]. However, its expression patterns differ in these situations [PMC7758130]. Mmu-mir-23b, along with mmu-miR-23a and mmu-miR-210, has been found to be involved in the crosstalk between ECs and NSPCs [PMC7758130]. It has also been implicated as critical for maintaining the glomerular filtration barrier [PMC2658734]. In a study on diet-induced obesity, mmu-mir-23b was found to be downregulated in obese mice compared to lean mice [PMC4571067]. In mice primordial germ cells (PGCs), exposure to vinclozolin during pregnancy led to a decrease in mmu-mir-23b expression, which downregulated the Lin28/let-7/Blimp1 PGC specification pathway across three generations [PMC9563050]. Mmu-mir-23b has a predicted binding site on the 3' untranslated region (3'UTR) of Runx2 mRNA at position 1002–1008 [PMC4768947]. Overall, mmu-mir-23b is involved in germ cell differentiation, crosstalk between ECs and NSPCs, glomerular filtration barrier maintenance, obesity-related miRNA dysregulation, PGC specification pathway regulation by environmental exposure, and potential regulation of Runx2 mRNA [PMC9505168][PMC7758130][PMC2658734][PMC4571067][PMC9563050][PMC4768947].

Genome locations

Gene Ontology annotations

Sequence

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AUCACAUUGCCAGGGAUUACC

Taxonomic tree

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This sequence is found in 29 other species

  1. Anolis carolinensis aca-miR-23b-3p
  2. Callithrix jacchus cja-miR-23b
  3. Callorhinchus milii (elephant shark) eshark_mir-23_1
  4. Capra hircus chi-miR-23b-3p
  5. Chiloscyllium plagiosum microRNA cpl-miR-23b
  6. Chrysemys picta (Painted turtle) cpi-miR-23b-3p
  7. Cricetulus griseus cgr-miR-23b-3p
  8. Cyprinus carpio ccr-miR-23b
  9. Daubentonia madagascariensis dma-miR-23b
  10. Equus caballus (horse) eca-miR-23b
  11. Gallus gallus (chicken) gga-miR-23b-3p
  12. Haplochromis burtoni abu-miR-23b
  13. Homo sapiens hsa-miR-23b-3p
  14. Ictalurus punctatus ipu-miR-23b
  15. Macaca mulatta mml-miR-23b-3p
  16. Maylandia zebra (zebra mbuna) mze-miR-23b
  17. Microcebus murinus mmr-miR-23b
  18. Monodelphis domestica mdo-miR-23b-3p
  19. Neolamprologus brichardi nbr-miR-23b
  20. Nomascus leucogenys nle-miR-23b
  21. Oreochromis niloticus (Nile tilapia) oni-miR-23b
  22. Ovis aries miscellaneous RNA
  23. Papio hamadryas pha-miR-23b
  24. Pundamilia nyererei pny-miR-23b
  25. Rattus norvegicus (Norway rat) rno-miR-23b-3p
  26. Taeniopygia guttata (zebra finch) tgu-miR-23-3p
  27. Tursiops truncatus miR-23b
  28. Xenopus laevis xla-miR-23b-3p
  29. Xenopus tropicalis xtr-miR-23b
Publications