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MIR16-2: To investigate the molecular mechanism of how R-2HG/ERĪ± decreases miR16-5p expression at the transcriptional level, Zhang et al. (2021) applied the Ensembl website with JASPAR database approaches to search for potential estrogen response elements (EREs) on the 3-kb region of miR16-1 and MIR16-2 promoters [PMC8479483]. Among the top 10 miRNAs with the highest absolute amount, MIR16-2 was identified [PMC8010072]. MIR16-2 is located on the intronic region of Structural Maintenance of Chromosomes 4 (SMC4) on chromosome 3 [PMC9553902]. Furthermore, CHORDC1 and MIR16-2 were found to be upregulated at D15 with fold changes of 4.54 [PMC8407676]. The expression levels of MIR16-2 were observed to be high during the S phase and gradually decrease during G2M and G1 phases in fibroblasts [PMC8713755]. In lung cancer, overexpression of BCL2 was associated with underexpression of MIR15A, MIR16-1, and MIR16-2 [PMC2683874]. Similarly, in kidney tumors, overexpression of DFFB, HTATIP, and RELA was related to underexpression of MIR124A-1, MIR124A-2, and MIR124A-3 [PMC2683874].
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