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Canis lupus familiaris (dog) cfa-miR-96 URS000016FF9C_9615

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cfa-mir-96: Cfa-mir-96 is an oncogenic miRNA that has been found to be highly conserved in both dogs and humans [PMC6827104]. In a study on canine mammary tumors (CMTs), it was observed that the expression of cfa-mir-96 was significantly increased in these tumors, which is consistent with its promoter hypomethylation [PMC6827104]. On the other hand, cfa-miR-149, a tumor-suppressive miRNA, showed decreased expression in CMTs, which is in line with its promoter hypermethylation [PMC6827104]. Among the top five predicted target genes of cfa-mir-96, three genes (BRPF3, ADCY6, and LRIG1) were found to be significantly downregulated in tumors compared to normal tissues [PMC6827104]. Similar to humans, it has been documented that miRNAs such as cfa-mir-96 and -149 are oncogenic and tumor-suppressive in dogs as well [PMC9610006]. Additionally, several differentially methylated regions (DMRs) were identified from the promoter regions of various miRNAs including cfa-mir-96 and cfa-miR-149 in CMT tissues [PMC9455804]. These findings suggest that cfa-mir-96 plays a role as an oncogenic miRNA in CMTs through its target genes and promoter hypomethylation. Conversely, cfa-miR-149 acts as a tumor-suppressive miRNA through its decreased expression and promoter hypermethylation. These observations highlight the importance of these miRNAs in canine mammary cancer progression.

Genome locations

Gene Ontology annotations

Sequence

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UUUGGCACUAGCACAUUUUUGCU

Taxonomic tree

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This sequence is found in 51 other species

  1. Alligator mississippiensis ami-miR-96-5p
  2. Bos taurus bta-miR-96
  3. Branchiostoma belcheri (Belcher's lancelet) bbe-miR-96-5p
  4. Branchiostoma floridae (Florida lancelet) bfl-miR-96-5p
  5. Branchiostoma lanceolatum Bla-Mir-96-P1_5p (mature (guide))
  6. Callithrix jacchus (white-tufted-ear marmoset) cja-miR-96
  7. Callorhinchus milii Cmi-Mir-96-P1_5p (mature (guide))
  8. Cavia porcellus cpo-miR-96-5p
  9. Cervus elaphus cel-miR-96
  10. Chrysemys picta bellii Cpi-Mir-96-P1_5p (mature (guide))
  11. Columba livia (rock pigeon) cli-miR-96-5p
  12. Cyprinus carpio ccr-miR-96
  13. Danio rerio (zebrafish) dre-miR-96-5p
  14. Dasypus novemcinctus (nine-banded armadillo) dno-miR-96-5p
  15. Echinops telfairi Ete-Mir-96-P1_5p (mature (guide))
  16. Equus caballus eca-miR-96
  17. Gadus morhua (Atlantic cod) gmo-miR-96-5p
  18. Gallus gallus (chicken) Gga-Mir-96-P1_5p (mature (guide))
  19. Gekko japonicus Gja-Mir-96-P1_5p (mature (guide))
  20. Haplochromis burtoni (Burton's mouthbrooder) abu-miR-96
  21. Homo sapiens hsa-miR-96-5p
  22. Ictalurus punctatus (channel catfish) ipu-miR-96
  23. Latimeria chalumnae Lch-Mir-96-P1_5p (mature (guide))
  24. Lepisosteus oculatus Loc-Mir-96-P1_5p (mature (guide))
  25. Macaca mulatta Mml-Mir-96-P1_5p (mature (guide))
  26. Maylandia zebra (zebra mbuna) mze-miR-96
  27. Microcaecilia unicolor Mun-Mir-96-P1_5p (mature (guide))
  28. Monodelphis domestica (gray short-tailed opossum) mdo-miR-96
  29. Monopterus albus Mal-Mir-96-P1b_5p (mature (guide))
  30. Mus musculus (house mouse) mmu-miR-96-5p
  31. Neolamprologus brichardi nbr-miR-96
  32. Ophiophagus hannah oha-miR-96
  33. Oreochromis niloticus oni-miR-96
  34. Ornithorhynchus anatinus oan-miR-96-5p
  35. Oryctolagus cuniculus ocu-miR-96-5p
  36. Pongo pygmaeus (Bornean orangutan) ppy-miR-96
  37. Pteropus alecto pal-miR-96-5p
  38. Pundamilia nyererei pny-miR-96
  39. Python bivittatus (Burmese python) pbv-miR-96-5p
  40. Rattus norvegicus (Norway rat) rno-miR-96-5p
  41. Salmo salar ssa-miR-96-5p
  42. Sarcophilus harrisii Sha-Mir-96-P1_5p (mature (guide))
  43. Scyliorhinus torazame Sto-Mir-96-P1_5p (mature (guide))
  44. Sphenodon punctatus (tuatara) Spt-Mir-96-P1_5p (mature (guide))
  45. Sus scrofa ssc-miR-96-5p
  46. Taeniopygia guttata (zebra finch) Tgu-Mir-96-P1_5p (mature (guide))
  47. Takifugu rubripes fru-miR-96
  48. Tetraodon nigroviridis (spotted green pufferfish) tni-miR-96
  49. Tor tambroides miR-96-5p
  50. Xenopus laevis xla-miR-96-5p
  51. Xenopus tropicalis (tropical clawed frog) xtr-miR-96
Publications