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Homo sapiens (human) CLDN10 antisense RNA 1 (CLDN10-AS1) URS000016D86A_9606

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CLDN10-AS1: CLDN10-AS1 is a differentially expressed long non-coding RNA (DElncRNA) that has been implicated in various aspects of lung adenocarcinoma (LUAD) [PMC5937496]. It has been shown to be upregulated in LUAD tissues [PMC8580341]. Additionally, CLDN10-AS1 has been found to be upregulated in LPS-treated human microvascular endothelial cells (HMECs) [PMC5632992]. CLDN10-AS1 has also been identified as a candidate lncRNA in atherosclerosis [PMC6389617]. It is associated with age, tumor stage, and lymphatic metastasis in LUAD patients [PMC5928764]. Furthermore, CLDN10-AS1 is involved in endothelial dysfunction and atherogenesis [PMC8556945]. Dysregulation of CLDN10-AS1 has also been reported in various types of cancers [PMC8556945]. In LUAD, CLDN10-AS1, along with SFTA1P and ADAMTS9-AS2, and their related mRNAs DLGAP5, E2F7, MCM7, RACGAP1, and RRM2 have prognostic value and may serve as biomarkers for the disease [PMC7053454]. Additionally, CLDN10-AS1 plays a role in the G1/S transition of the mitotic cell cycle through miR-125b-5p/PPAT regulation and regulates endothelium development through miR-125b-5p/CDH5 regulation [PMC7053454]. Furthermore, CLDN10-AS1 is associated with poor prognosis in LUAD patients [PMC7053454][PM9869594]. References: [PM9869594] [PM7053454] [PM5928764] [PM8556945] [PM6389617] [PM5632992] [PM8580341] [PMC5937496]

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Gene Ontology annotations


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