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mmu-mir-470: Mmu-mir-470 is a validated miRNA that has been shown to be a potential candidate for protein Oct4, as it is in the same cluster as mmu-miR-203, 330, 342, 10a, and 99b [PMC3937077]. It has been experimentally validated and numerically validated by a TI model [PMC3937077]. In contrast to mmu-mir-470, other miRNAs such as mmu-let-7b and mmu-miR-181a have been experimentally validated for protein GCNF [PMC3937077]. For protein Nanog, the experimentally validated miRNAs are mmu-miR-134, mmu-mir-470, and mmu-miR-296 [PMC3937077]. Mmu-mir-470 shares the same seed sequence as miR-T1-3p [PMC5915558]. Additionally, bioinformatics analysis has shown that mmu-mir-470 targets TGIF1 in the regulation of TGF-beta signaling [PMC4499447]. On the other hand, miRNAs such as mmu-miR134 and mmu-miR21 have been found to inhibit genes related to pluripotency such as Nanog and Sox2 in cell differentiation processes [PMC9505168].
References:
[PMC3937077] - TarBase database
[PMC5915558] - Article on miRNA seed sequence analysis
[PMC4499447] - Bioinformatics analysis of miRNA targets
[PMC9505168] - Study on pluripotency genes regulation by miRNAs
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