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Homo sapiens (human) microRNA hsa-mir-29b precursor (hsa-mir-29b-1) URS0000150A7D_9606

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MIR29B1: MIR29B1 is a microRNA that has been observed to be downregulated in Alzheimer's disease (AD) patients [PMC7564652]. It has been found to target secretases, which are involved in AD pathogenesis, as well as have a protective effect on neuron survival [PMC7564652]. Additionally, MIR29B1 has been shown to regulate BACE1 expression, a gene involved in AD, in vitro [PMC7564652]. In the cortex of AD patients, MIR29B1 is downregulated along with other microRNAs such as MIR129-2, MIR1296, MIR219A1, MIR375, MIR411, and MIR431 [PMC7564652]. Conversely, microRNAs such as MIR199A2 and MIR92A1 are upregulated in the cortex of AD patients [PMC7564652]. In other contexts, such as dairy cattle domestication and breast cancer cells (MDA-MB-231S), upregulation of MIR29B1 has been observed [PMC6898964] [PMC4651668]. It is also a host gene for miR-22 and miR-29b which are downregulated in certain diseases like SMZL (splenic marginal zone lymphoma) [PMC7111612] [PMC8064455]. In rats with a homozygous mutation of the Mir29b-1/a gene that encodes nucleotides 6–9 in the sequence of mature miR-29b-3p (MIR29B1), reduced urine volume and urinary sodium excretion were observed due to reduced NO levels in the renal outer medulla [PMC6156712].

Genome locations

Gene Ontology annotations

Sequence

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CUUCAGGAAGCUGGUUUCAUAUGGUGGUUUAGAUUUAAAUAGUGAUUGUCUAGCACCAUUUGAAAUCAGUGUUCUUGGGGG

Taxonomic tree

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This sequence is found in 63 other species

  1. Aotus nancymaae (Ma's night monkey) miRNA (ENSANAG00000014030.1)
  2. Ateles geoffroyi microRNA age-mir-29b precursor
  3. Bos taurus microRNA bta-mir-29b precursor (bta-mir-29b-1)
  4. Capra hircus microRNA 29b-1 (ENSCHIG00000009164.1)
  5. Carlito syrichta (Philippine tarsier) miRNA (ENSTSYG00000026059.1)
  6. Cebus imitator microRNA 29b-1 (ENSCCAG00000002159.1)
  7. Cercocebus atys miRNA (ENSCATG00000008809.1)
  8. Chlorocebus sabaeus microRNA 29b-1 (ENSCSAG00000027654.1)
  9. Colobus angolensis palliatus miRNA (ENSCANG00000005717.1)
  10. Equus caballus (horse) microRNA eca-mir-29b precursor
  11. Gorilla gorilla gorilla (Western Lowland Gorilla) ggo-mir-29b-1 (ENSGGOG00000034324.2)
  12. Gorilla gorilla microRNA ggo-mir-29b precursor (ggo-mir-29b-1)
  13. Lagothrix lagotricha (brown woolly monkey) microRNA lla-mir-29b precursor
  14. Loxodonta africana microRNA 29b-1 (ENSLAFG00000024071.1)
  15. Macaca mulatta (Rhesus monkey) microRNA mml-mir-29b precursor (mml-mir-29b-1)
  16. Macaca nemestrina miRNA (ENSMNEG00000007424.1)
  17. Mandrillus leucophaeus (Drill) miRNA (ENSMLEG00000002577.1)
  18. Microcebus murinus microRNA 29b-1 (ENSMICG00000018084.3)
  19. Nomascus leucogenys (Northern white-cheeked gibbon) microRNA 29b-1 (ENSNLEG00000022424.2)
  20. Otolemur garnettii (small-eared galago) miRNA (ENSOGAG00000020823.1)
  21. Ovis aries (sheep) miRNA (ENSOARG00000022267.1)
  22. Pan paniscus microRNA ppa-mir-29b precursor (ppa-mir-29b-1)
  23. Panthera pardus (leopard) microRNA 29b-1 (ENSPPRG00000014477.1)
  24. Panthera tigris altaica miRNA (ENSPTIG00000001757.1)
  25. Pan troglodytes microRNA ptr-mir-29b precursor (ptr-mir-29b-1)
  26. Pongo abelii (Sumatran orangutan) miRNA
  27. Pongo pygmaeus (Bornean orangutan) microRNA ppy-mir-29b precursor (ppy-mir-29b-1)
  28. Propithecus coquereli (Coquerel's sifaka) miRNA (ENSPCOG00000009588.1)
  29. Pteropus vampyrus (large flying fox) miRNA (ENSPVAG00000027791.1)
  30. Rhinopithecus bieti miRNA (ENSRBIG00000009855.1)
  31. Rhinopithecus roxellana (Golden snub-nosed monkey) miRNA (ENSRROG00000006154.1)
  32. Saimiri boliviensis boliviensis miRNA (ENSSBOG00000010900.1)
Publications