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Homo sapiens (human) microRNA hsa-mir-196a precursor (hsa-mir-196a-1) URS000014C145_9606

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MIR196A1: MIR196A1 is a member of the MIR196 gene family, which includes MIR196A1, MIR196A2, and MIR196B. It is a noncoding RNA derived from the HOXB gene cluster on chromosome 17 in humans. [PMC4413621]. Studies have identified MIR196A1 as a potential biomarker for several diseases, including hepatocellular carcinoma, leukemia, lung cancer, breast cancer, colorectal cancer, and pancreatic adenocarcinoma [PMC10134363]. The expression of MIR196A1 can be influenced by genetic variations and is correlated with HOXB7 and HOXB8 expression [PMC5551414]. It has also been associated with adipogenesis and body fat distribution [PMC5551414]. The miR-196 family includes miR-196a-2 (encoded by MIR196A2) and miR-196b (encoded by MIR196B), which share identical seed sequences with miR-196a1 [PMC6080909]. Aberrant methylation of the CpG sites in the RUNX3 and MIR196A1 genes has been observed in relation to smoking cessation [PMC5960087]. Additionally, the combination of VAT1L, CALR, LINC01456, RP11-484L8.1, MIR148A, and MIR 19 6 A 1 has been associated with overall survival in pancreatic cancer patients [PMC5641173]. Overall,MIR19 6 A 1 plays a role in various diseases as a potential biomarker or regulator of gene expression.

Genome locations

Gene Ontology annotations

Sequence

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GUGAAUUAGGUAGUUUCAUGUUGUUGGGCCUGGGUUUCUGAACACAACAACAUUAAACCACCCGAUUCAC

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This sequence is found in 28 other species

Publications