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Homo sapiens (human) RNA, U4 small nuclear 2 (RNU4-2) secondary structure diagram

Homo sapiens (human) RNA, U4 small nuclear 2 (RNU4-2) URS0000149178_9606

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RNU4-2: RNU4-2 is a member of the small nuclear U4 RNA family and is involved in pre-mRNA intron splicing regulation [PMC9803687]. In ilBC samples, RNU4-2 was found to be upregulated compared to benign breast tissue [PMC9803687]. Higher levels of RNU4-2 have also been associated with poorer prognosis in colon cancer tissue [PMC9803687]. The levels of RNU4-2 were measured after treating cells with ActD to observe changes in Prx1-associated snRNAs and mRNAs at the post-transcriptional level [PMC6690714]. RNU4-2 is one of the major snRNAs, along with U5, encoded by the RNU4-2 and RNU5D-1 genes [PMC9881141]. No information about RNU4-2 in breast or other cancers was found in PubMed or the NURSA Transcriptomine database [PMC5966448]. Deletion of a single T-run from an RNU4-2 reporter plasmid caused an enhancement of read-through, suggesting a functional role for such elements in termination [PMC7610016]. In COAD patients, RNU4-2 was identified as one of the core genes associated with initial lymphatic metastasis and potential biomarkers for COAD [PMC9444393]. The expression of mRNA differed between COAD tissues and RNU4-2 [PMC9444393]. Additionally, RNU4-2 is involved in RNA processing related to suicide and autism [PMC9444393]. Overall, these findings highlight the importance of studying the role and expression levels of RNU4-2 in various diseases [PMC9803687, PMC6690714, PMC9881141, PMC5966448, PMC7610016, PMC9444393].

Genome locations

Gene Ontology annotations

Sequence

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AGCUUUGCGCAGUGGCAGUAUCGUAGCCAAUGAGGUUUAUCCGAGGCGCGAUUAUUGCUAAUUGAAAACUUUUCCCAAUACCCCGCCAUGACGACUUGAAAUAUAGUCGGCAUUGGCAAUUUUUGACAGUCUCUACGGAGA

Taxonomic tree

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This sequence is found in 181 other species

  1. Ailuropoda melanoleuca U4 spliceosomal RNA (ENSAMEG00000027461.1)
  2. Aotus nancymaae (Ma's night monkey) U4 spliceosomal RNA (ENSANAG00000003754.1)
  3. Balaenoptera musculus U4 spliceosomal RNA (ENSBMSG00010009247.1)
  4. Callithrix jacchus U4 spliceosomal RNA (ENSCJAG00000080088.1)
  5. Camelus dromedarius U4 spliceosomal RNA (ENSCDRG00005018216.1)
  6. Camelus ferus U4 spliceosomal RNA
  7. Canis lupus dingo U4 spliceosomal RNA (ENSCAFG00020020568.1)
  8. Canis lupus familiaris U4 spliceosomal RNA (ENSCAFG00000059403.1, ENSCAFG00030023857.1, ENSCAFG00040019816.1, ENSCAFG00845029640.1)
  9. Capra hircus U4 spliceosomal RNA (ENSCHIG00000000778.1)
  10. Castor canadensis (American beaver) U4 spliceosomal RNA (ENSCCNG00000019160.1)
  11. Catagonus wagneri (Chacoan peccary) U4 spliceosomal RNA (ENSCWAG00000014415.1)
  12. Cavia porcellus U4 spliceosomal RNA (ENSCPOG00000031308.1)
  13. Cebus imitator U4 spliceosomal RNA (ENSCCAG00000005140.1)
  14. Cercocebus atys U4 spliceosomal RNA (ENSCATG00000005075.1)
  15. Cervus hanglu yarkandensis U4 spliceosomal RNA (ENSCHYG00000003014.1)
  16. Chlorocebus sabaeus U4 spliceosomal RNA (ENSCSAG00000027279.1)
  17. Colobus angolensis palliatus U4 spliceosomal RNA (ENSCANG00000015989.1)
  18. Cricetulus griseus (Chinese hamster) U4 spliceosomal RNA (ENSCGRG00001003865.1, ENSCGRG00015037903.1)
  19. Delphinapterus leucas U4 spliceosomal RNA (ENSDLEG00000017876.1)
  20. Erinaceus europaeus U4 spliceosomal RNA (ENSEEUG00000016307.1, ENSEEUG00000017001.1)
  21. Felis catus (domestic cat) U4 spliceosomal RNA (ENSFCAG00000042780.1)
  22. Fukomys damarensis U4 spliceosomal RNA (ENSFDAG00000003218.1)
  23. Gorilla gorilla gorilla U4 spliceosomal RNA (ENSGGOG00000037864.1)
  24. Heterocephalus glaber U4 spliceosomal RNA (ENSHGLG00000032033.1, ENSHGLG00000032227.1, ENSHGLG00100046822.1, ENSHGLG00100051441.1)
  25. Ictidomys tridecemlineatus U4 spliceosomal RNA (ENSSTOG00000029029.1)
  26. Laticauda laticaudata U4 spliceosomal RNA (ENSLLTG00000000244.1)
  27. Lynx canadensis (Canada lynx) U4 spliceosomal RNA (ENSLCNG00005020385.1)
  28. Macaca fascicularis (Crab-eating macaque) U4 spliceosomal RNA (ENSMFAG00000064901.1)
  29. Macaca mulatta U4 spliceosomal RNA (ENSMMUG00000049453.1)
  30. Macaca nemestrina U4 spliceosomal RNA (ENSMNEG00000011112.1)
  31. Mandrillus leucophaeus (Drill) U4 spliceosomal RNA (ENSMLEG00000010786.1)
  32. Marmota marmota marmota U4 spliceosomal RNA (ENSMMMG00000021130.1)
  33. Marmota monax (woodchuck) non-coding RNA
  34. Microcebus murinus (gray mouse lemur) U4 spliceosomal RNA
  35. Microtus ochrogaster (vole) U4 spliceosomal RNA (ENSMOCG00000009401.1)
  36. Monodelphis domestica U4 spliceosomal RNA (ENSMODG00000041301.1)
  37. Monodon monoceros U4 spliceosomal RNA (ENSMMNG00015011319.1)
  38. Moschus moschiferus (Siberian musk deer) U4 spliceosomal RNA (ENSMMSG00000014199.1)
  39. Mus caroli U4 spliceosomal RNA (MGP_CAROLIEiJ_G0035390.1)
  40. Mus musculus (mouse) predicted gene, 24407 (ENSMUSG00000119132.1)
  41. Mus spicilegus (steppe mouse) U4 spliceosomal RNA (ENSMSIG00000011105.1)
  42. Mus spretus (algerian mouse) predicted gene, 24407 (MGP_SPRETEiJ_G0036290.1)
  43. Mustela putorius furo U4 spliceosomal RNA (ENSMPUG00000021298.1)
  44. Naja naja U4 spliceosomal RNA (ENSNNAG00000018568.1)
  45. Nannospalax galili U4 spliceosomal RNA (ENSNGAG00000010487.1)
  46. Neotoma lepida U4 spliceosomal RNA
  47. Neogale vison (American mink) U4 spliceosomal RNA (ENSNVIG00000009574.1)
  48. Notechis scutatus U4 spliceosomal RNA (ENSNSUG00000000827.1)
  49. Octodon degus (Degu) U4 spliceosomal RNA (ENSODEG00000025764.1)
  50. Ophiophagus hannah U4 spliceosomal RNA
  51. Ornithorhynchus anatinus U4 spliceosomal RNA (ENSOANG00000048221.1)
  52. Otolemur garnettii U4 spliceosomal RNA (ENSOGAG00000020605.2)
  53. Ovis aries (sheep) U4 spliceosomal RNA (ENSOARG00020013351.1, ENSOARG00020021838.1)
  54. Pan paniscus U4 spliceosomal RNA (ENSPPAG00000000048.1)
  55. Panthera leo U4 spliceosomal RNA (ENSPLOG00000009256.1)
  56. Panthera pardus (leopard) U4 spliceosomal RNA (ENSPPRG00000022327.1)
  57. Panthera tigris altaica U4 spliceosomal RNA (ENSPTIG00000002169.1)
  58. Pan troglodytes (chimpanzee) U4 spliceosomal RNA (ENSPTRG00000045043.1)
  59. Papio anubis U4 spliceosomal RNA (ENSPANG00000051005.1)
  60. Peromyscus maniculatus bairdii U4 spliceosomal RNA (ENSPEMG00000030892.1)
  61. Phascolarctos cinereus U4 spliceosomal RNA (ENSPCIG00000035217.1)
  62. Phocoena sinus (vaquita) U4 spliceosomal RNA (ENSPSNG00000006947.1)
  63. Physeter catodon (sperm whale) U4 spliceosomal RNA (ENSPCTG00005019938.1)
  64. Piliocolobus tephrosceles U4 spliceosomal RNA (ENSPTEG00000000865.1, ENSPTEG00000039046.1)
  65. Pongo abelii U4 spliceosomal RNA (ENSPPYG00000031748.1)
  66. Prolemur simus (greater bamboo lemur) U4 spliceosomal RNA (ENSPSMG00000001528.1)
  67. Propithecus coquereli (Coquerel's sifaka) U4 spliceosomal RNA (ENSPCOG00000012199.1)
  68. Pseudonaja textilis (eastern brown snake) U4 spliceosomal RNA (ENSPTXG00000016043.1, ENSPTXG00000016044.1)
  69. Pteropus alecto U4 spliceosomal RNA
  70. Pteropus vampyrus U4 spliceosomal RNA (ENSPVAG00000025328.1)
  71. Rattus norvegicus U4 spliceosomal RNA (ENSRNOG00000069182.1)
  72. Rhinolophus ferrumequinum U4 spliceosomal RNA (ENSRFEG00010014680.1)
  73. Rhinopithecus bieti U4 spliceosomal RNA (ENSRBIG00000007917.1)
  74. Rhinopithecus roxellana (Golden snub-nosed monkey) U4 spliceosomal RNA (ENSRROG00000001636.1)
  75. Saimiri boliviensis boliviensis (Bolivian squirrel monkey) U4 spliceosomal RNA (ENSSBOG00000015134.1)
  76. Salvator merianae U4 spliceosomal RNA (ENSSMRG00000016565.1)
  77. Sarcophilus harrisii U4 spliceosomal RNA (ENSSHAG00000024405.1)
  78. Sciurus vulgaris U4 spliceosomal RNA (ENSSVLG00005008110.1)
  79. Sorex araneus U4 spliceosomal RNA (ENSSARG00000015064.1)
  80. Suricata suricatta (meerkat) U4 spliceosomal RNA (ENSSSUG00005015010.1)
  81. Sus scrofa U4 spliceosomal RNA (multiple genes)
  82. Theropithecus gelada (gelada) U4 spliceosomal RNA (ENSTGEG00000022972.1)
  83. Tursiops truncatus (bottlenosed dolphin) U4 spliceosomal RNA (ENSTTRG00000021516.1, ENSTTRG00000021623.1)
  84. Urocitellus parryii U4 spliceosomal RNA (ENSUPAG00010017085.1)
  85. Ursus americanus (American black bear) U4 spliceosomal RNA (ENSUAMG00000019306.1)
  86. Ursus maritimus (Polar bear) U4 spliceosomal RNA (ENSUMAG00000006217.1)
  87. Ursus thibetanus thibetanus U4 spliceosomal RNA (ENSUTTG00000006360.1)
  88. Vicugna pacos (alpaca) U4 spliceosomal RNA (ENSVPAG00000017059.1)
  89. Vombatus ursinus U4 spliceosomal RNA (ENSVURG00010006619.1)
  90. Vulpes vulpes (red fox) U4 spliceosomal RNA (ENSVVUG00000020986.1)
  91. Zalophus californianus U4 spliceosomal RNA (ENSZCAG00015020097.1)
2D structure Publications