RNU4-2: RNU4-2 is a member of the small nuclear U4 RNA family and is involved in pre-mRNA intron splicing regulation [PMC9803687]. In ilBC samples, RNU4-2 was found to be upregulated compared to benign breast tissue [PMC9803687]. Higher levels of RNU4-2 have also been associated with poorer prognosis in colon cancer tissue [PMC9803687]. The levels of RNU4-2 were measured after treating cells with ActD to observe changes in Prx1-associated snRNAs and mRNAs at the post-transcriptional level [PMC6690714]. RNU4-2 is one of the major snRNAs, along with U5, encoded by the RNU4-2 and RNU5D-1 genes [PMC9881141]. No information about RNU4-2 in breast or other cancers was found in PubMed or the NURSA Transcriptomine database [PMC5966448]. Deletion of a single T-run from an RNU4-2 reporter plasmid caused an enhancement of read-through, suggesting a functional role for such elements in termination [PMC7610016]. In COAD patients, RNU4-2 was identified as one of the core genes associated with initial lymphatic metastasis and potential biomarkers for COAD [PMC9444393]. The expression of mRNA differed between COAD tissues and RNU4-2 [PMC9444393]. Additionally, RNU4-2 is involved in RNA processing related to suicide and autism [PMC9444393]. Overall, these findings highlight the importance of studying the role and expression levels of RNU4-2 in various diseases [PMC9803687, PMC6690714, PMC9881141, PMC5966448, PMC7610016, PMC9444393].
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