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Homo sapiens (human) small nucleolar RNA, H/ACA box 74A (SNORA74A) secondary structure diagram

Homo sapiens (human) small nucleolar RNA, H/ACA box 74A (SNORA74A) URS0000148398_9606

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SNORA74A: SNORA74A is a dysregulated snoRNA that has been associated with shorter progression-free survival (PFS) in chronic lymphocytic leukemia (CLL) patients [1]. It is one of several dysregulated snoRNAs, including SNORD116-18, SNORA70F, SNORD56, and SNORD1A, that have been identified as potential targets for leukemia therapy [1]. In acute myeloid leukemia (AML), it has been reported that SNORD114-1 regulates the cell cycle transition mediated by the Rb/p16 pathway [1]. Furthermore, studies on the sno/scaRNA profile have revealed dysregulated snoRNAs in different subtypes of leukemia, including SNORD109A, SNORD64, SNORD107, SNORA31, SNORA6, SNORA62, SNORA71C, and more [1] [2]. In terms of correlations with other biomarkers in pancreatic cancer patients measured by CA19-9 levels in serum samples, there were no significant correlations between the serum levels of RNAs WASF2 and ARF6 and CA19‐9 levels [3]. However, a significant correlation was observed between CA19‐9 levels and the serum levels of both RNAs WASF2 (R=0.221; 95% CI 0.100–0.500) and ARF6 (R=0.136; 95% CI 0.183–0.429) [3]. Additionally, a stronger correlation was observed between CA19‐9 levels and the serum level of SNORA74A (R=0.600; 95% CI 0.354–0.768) and SNORA25 (R=0.358; 95% CI 0.053–0.603) [2] [3].

mRNA interactions 1 total

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Gene Ontology annotations



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2D structure Publications