Sorry, there was a problem loading sequence from server. Please try again and contact us if the problem persists.
Homo sapiens (human) ribonuclease P RNA component H1 (RPPH1) secondary structure diagram

Homo sapiens (human) ribonuclease P RNA component H1 (RPPH1) URS000013F331_9606

Caution, this is an AI generated summary based on literature. This may have errors, see here for more. Please share your feedback with us.

RPPH1: RPPH1 is a long non-coding RNA (lncRNA) that has been implicated in various biological processes and diseases. It has been shown to bind to miR-542-3p in hypoxia-induced PC12 cells [PMC9014715]. Plasma exosomal RPPH1 has been found to exhibit higher sensitivity and specificity [PMC6828701]. Exosomes derived from colorectal cancer (CRC) cells transport RPPH1 into macrophages and mediate M2-like polarization, promoting CRC cell proliferation and metastasis [PMC8313969]. RPPH1 has also been shown to promote inflammation in mesangial cells under low-glucose conditions, while its knockdown inhibits inflammation under high-glucose conditions [PMC8548175]. Hsa_circRNA_002144, a circRNA produced by the RPPH1 gene, is upregulated in hepatocellular carcinoma [PMC8086769]. Elevated levels of RPPH1 have been associated with poor overall survival in esophageal cancer patients receiving radiotherapy [PMC7183868]. Knockdown of RPPH1 using sh-RPPH1-1 was used for further analysis [PMC6806202]. High expression of RPPH1 in advanced TNM stage is associated with poor metastasis and overall survival [PMC8847166]. In breast cancer, RPPH1 is speculated to play a significant role in tumor biology [PMC5698957]. The performance of the swabbing procedure was checked using real-time RT-PCR detecting the human ribonuclease P RNA component H1 (RPPH1) gene on chromosome 14 [PMC8230487]. The exact mechanism of how RPPH1 RNA is transported to or out of mitochondria needs further study, but its shifting from the cytoplasm to mitochondria is associated with cellular senescence [PMC7828772].

mRNA interactions 2 total

Genome locations

Gene Ontology annotations


Sequence features are shown above as colored rectangles. Zoom in and click to view details, or Reset

Search for similar sequences

Taxonomic tree

View annotations in different species by clicking on species names.

Scroll around to explore the entire tree. Click tree nodes to collapse or expand them. Hover over taxon names to display additional information.

2D structure Publications