RPPH1: RPPH1 is a long non-coding RNA (lncRNA) that has been implicated in various biological processes and diseases. It has been shown to bind to miR-542-3p in hypoxia-induced PC12 cells [PMC9014715]. Plasma exosomal RPPH1 has been found to exhibit higher sensitivity and specificity [PMC6828701]. Exosomes derived from colorectal cancer (CRC) cells transport RPPH1 into macrophages and mediate M2-like polarization, promoting CRC cell proliferation and metastasis [PMC8313969]. RPPH1 has also been shown to promote inflammation in mesangial cells under low-glucose conditions, while its knockdown inhibits inflammation under high-glucose conditions [PMC8548175]. Hsa_circRNA_002144, a circRNA produced by the RPPH1 gene, is upregulated in hepatocellular carcinoma [PMC8086769]. Elevated levels of RPPH1 have been associated with poor overall survival in esophageal cancer patients receiving radiotherapy [PMC7183868]. Knockdown of RPPH1 using sh-RPPH1-1 was used for further analysis [PMC6806202]. High expression of RPPH1 in advanced TNM stage is associated with poor metastasis and overall survival [PMC8847166]. In breast cancer, RPPH1 is speculated to play a significant role in tumor biology [PMC5698957]. The performance of the swabbing procedure was checked using real-time RT-PCR detecting the human ribonuclease P RNA component H1 (RPPH1) gene on chromosome 14 [PMC8230487]. The exact mechanism of how RPPH1 RNA is transported to or out of mitochondria needs further study, but its shifting from the cytoplasm to mitochondria is associated with cellular senescence [PMC7828772].
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