hsa-mir-216a: Hsa-mir-216a is highly enriched in KLEC derived exosomes [PMC5570218]. It has been found to be closely related to target DEmRNAs, along with other microRNAs such as hsa-mir-217, hsa-mir-133b, hsa-mir-133a, hsa-mir-145, hsa-mir-211, and hsa-mir-1297 [PMC5565391]. In a study on pancreatic adenocarcinoma, significant differences in expression profiles of hsa-mir-216a were observed between tumor and normal groups [PMC9669652]. The function of hsa-mir-216a may be modulated by microRNA interference, as predicted by TargetScan [PMC5062913]. In another study on papillary renal cell carcinoma (PRCC), hsa-miR-211 and five DEmiRNAs (hsa-miR-145, hsa-miR-184, hsa-mir-214, hsa-mir-216a, hsa-miR-217) were significantly associated with overall survival [PMC6522832]. Additionally, the upregulation of hsa-miR-135b and hsa-mir-216a expression was positively correlated with overall survival in PRCC patients [PMC7499949]. These findings highlight the potential significance of hsa-mir-216a in various cancer types.
MIR216A: MIR216A is a microRNA that has been implicated in various biological processes and diseases, including drug resistance, tumor growth suppression, and regulation of autophagy and apoptosis pathways [PMC9188773] [PMC3912413] [PMC6832453]. It has also been associated with 5-year survival rates in certain cancer patients [PMC6552362]. MIR216A can target genes involved in the Wnt/β-catenin pathway and stemness of cancer cells [PMC3912413]. Furthermore, it has been implicated in the regulation of endothelial cell senescence and atherosclerosis progression [PMC8001288] [PMC9735883]. The expression of MIR216A can be regulated by other factors such as long non-coding RNAs and transcription factors like SREBP1c [PMC9820553]. Additionally, MIR216A has been shown to be involved in the regulation of immune responses through its correlation with infiltrated T cells [PMC7093482]. Overall, the role of MIR216A appears to be context-dependent as it can function as both an oncogene and a tumor suppressor depending on the specific tumor type or biological process being studied [PMC8235499].
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