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Canis lupus familiaris (dog) cfa-miR-346 URS0000134ADC_9615

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cfa-mir-346: Cfa-mir-346, a microRNA, is induced in canine macrophage-like cells upon infection with live parasites, specifically Leishmania spp [PMC9235276]. The induction of cfa-mir-346 in these cells is not associated with the induction of the endoplasmic reticulum (ER) stress marker sXBP1 [PMC9235276]. In dogs, cfa-mir-346 has been found to be upregulated in cardiac hypertrophy [PMC9235276] [PMC8542680]. The upregulation of cfa-mir-346 was observed in a canine macrophage-like cell line (DH82) infected with Leishmania spp, regardless of the strain or time point tested [PMC9235276]. The induction of cfa-mir-346 was not observed in response to ER stress induction with tunicamycin [PMC9235276]. Cfa-mir-346 is located within the glutamate ionotropic receptor delta type subunit 1 (GRID1) gene [PMC9235276]. In clinical samples, an increase in cfa-mir-346 expression levels was detected in the plasma of dogs infected with Leishmania spp, suggesting its potential as a non-invasive marker of infection [PMC9235276]. However, further studies are needed to understand its role during Leishmania infection and evaluate its specificity as a biomarker for canine leishmaniasis [PMC9235276].

Genome locations

Gene Ontology annotations


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This sequence is found in 11 other species

  1. Bos taurus (cattle) bta-miR-346
  2. Capra hircus chi-miR-346-5p
  3. Cavia porcellus cpo-miR-346-5p
  4. Equus caballus (horse) eca-miR-346
  5. Homo sapiens (human) hsa-miR-346
  6. Macaca mulatta mml-miR-346
  7. Oryctolagus cuniculus (rabbit) ocu-miR-346-5p
  8. Pan troglodytes (chimpanzee) ptr-miR-346
  9. Pongo pygmaeus (Bornean orangutan) ppy-miR-346
  10. Pteropus alecto pal-miR-346-5p
  11. Sus scrofa (pig) ssc-mir165