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hsa-mir-4644: Hsa-mir-4644 is an overexpressed microRNA that has been found to increase cell proliferation and survival by inhibiting the expression of UbiA prenyltransferase domain-containing protein 1 (UBIAD1) [PMC9198802]. In addition to hsa-mir-4644, there are several other human microRNAs that are similar to those found in Toxoplasma gondii, including hsa-miR-6873, hsa-miR-328, hsa-miR-7107-3p, hsa-miR-6821-5p [PMC9198802]. A study on acute Kawasaki disease (KD) revealed that hsa-mir-4644 is one of the seven microRNAs significantly upregulated in plasma compared to healthy controls [PMC8266996]. The other upregulated microRNAs were hsa-let7b5p, hsa-miR2233p, hsa-miR4485, hsa-mir4644, hsamiR48005p, hsamiR65105p and hsamiR765. On the other hand, three microRNAs were significantly downregulated in acute KD plasma compared to healthy controls: hasmiR33b3p, hasmiR4443 and hasmiR4515 [PMC8266996]. These findings suggest that dysregulation of microRNA expression may play a role in the pathogenesis of acute KD.
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