rno-let-7d: Rno-let-7d is a miRNA that has been found to be upregulated in response to a hyperandrogenic condition in granulosa cells [PMC3682887]. This upregulation is believed to be associated with the downregulation of androgen receptors [PMC3682887]. Rno-let-7d is also highly abundant in DHT-treated ovaries [PMC3682887]. In addition, rno-let-7d has been found to have experimentally validated targets, including Homer 1a, which may be related to the ADHD phenotype [PMC3682887] [PMC8858317]. Furthermore, rno-let-7d has shown differential expression in adipose tissue of sensitized rats, being upregulated along with rno-miR-423 and downregulated along with rno-miR-99a [PMC7564923]. Animal studies have also demonstrated that miRNA expression of rno-let-7d or its target genes, such as Homer 1a, are associated with ADHD phenotypes in animal models [PMC5987559]. Overall, rno-let-d is a miRNA that plays a role in the regulation of androgen receptors and may have implications for conditions such as hyperandrogenism and ADHD.
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