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Rattus norvegicus (Norway rat) rno-let-7d-5p URS00000A07C1_10116

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rno-let-7d: Rno-let-7d is a miRNA that has been found to be upregulated in response to a hyperandrogenic condition in granulosa cells [PMC3682887]. This upregulation is believed to be associated with the downregulation of androgen receptors [PMC3682887]. Rno-let-7d is also highly abundant in DHT-treated ovaries [PMC3682887]. In addition, rno-let-7d has been found to have experimentally validated targets, including Homer 1a, which may be related to the ADHD phenotype [PMC3682887] [PMC8858317]. Furthermore, rno-let-7d has shown differential expression in adipose tissue of sensitized rats, being upregulated along with rno-miR-423 and downregulated along with rno-miR-99a [PMC7564923]. Animal studies have also demonstrated that miRNA expression of rno-let-7d or its target genes, such as Homer 1a, are associated with ADHD phenotypes in animal models [PMC5987559]. Overall, rno-let-d is a miRNA that plays a role in the regulation of androgen receptors and may have implications for conditions such as hyperandrogenism and ADHD.

Genome locations

Gene Ontology annotations

Sequence

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AGAGGUAGUAGGUUGCAUAGUU

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This sequence is found in 70 other species

  1. Alligator mississippiensis (American alligator) Ami-Let-7-P2c1_5p (mature (guide))
  2. Anolis carolinensis (green anole) Aca-Let-7-P2c1_5p (mature (guide))
  3. Bos taurus (cattle) bta-let-7d
  4. Callithrix jacchus (white-tufted-ear marmoset) cja-let-7d
  5. Callorhinchus milii Cmi-Let-7-P2c1_5p (mature (guide))
  6. Canis lupus familiaris (dog) Cfa-Let-7-P2c1_5p (mature (guide))
  7. Capra hircus (goat) chi-let-7d-5p
  8. Cavia porcellus (domestic guinea pig) cpo-let-7d-5p
  9. Cervus elaphus (red deer) cel-let-7d
  10. Chiloscyllium plagiosum microRNA cpl-let-7d-5p
  11. Chrysemys picta bellii (western painted turtle) Cpi-Let-7-P2c1_5p (mature (guide))
  12. Chrysemys picta cpi-let-7d-5p
  13. Columba livia (rock pigeon) cli-let-7d-5p
  14. Cricetulus griseus cgr-let-7d-5p
  15. Dasypus novemcinctus (nine-banded armadillo) dno-let-7d-5p
  16. Echinops telfairi Ete-Let-7-P2c1_5p (mature (guide))
  17. Equus caballus (horse) eca-let-7d
  18. Gekko japonicus Gja-Let-7-P2c1_5p (mature (guide))
  19. Homo sapiens (human) hsa-let-7d-5p
  20. Latimeria chalumnae Lch-Let-7-P2c1_5p (mature (guide))
  21. Macaca mulatta (Rhesus monkey) mml-let-7d
  22. Microcaecilia unicolor Mun-Let-7-P2c1_5p (mature (guide))
  23. Monodelphis domestica Mdo-Let-7-P2c1_5p (mature (guide))
  24. Mus musculus mmu-let-7d-5p
  25. Ophiophagus hannah (king cobra) oha-let-7d-5p
  26. Ornithorhynchus anatinus oan-let-7d-5p
  27. Oryctolagus cuniculus (rabbit) ocu-let-7d-5p
  28. Pan troglodytes (chimpanzee) ptr-let-7d
  29. Pongo pygmaeus ppy-let-7d
  30. Python bivittatus (Burmese python) pbv-let-7d-5p
  31. Sarcophilus harrisii Sha-Let-7-P2c1_5p (mature (guide))
  32. Scyliorhinus torazame (cloudy catshark) Sto-Let-7-P2c1_5p (mature (guide))
  33. Sphenodon punctatus Spt-Let-7-P2c1_5p (mature (guide))
  34. Sus scrofa ssc-let-7d-5p
  35. Taeniopygia guttata tgu-let-7d-5p
Publications