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Homo sapiens (human) long intergenic non-protein coding RNA 616 (LINC00616) URS000007DDD8_9606

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LINC00616: LINC00616 is a long non-coding RNA (lncRNA) that has been identified in various studies [PMC7516207] [PMC7991845] [PMC9276003]. It is located in the proximity of protein-coding genes MSRA, SLC7A11, EPAS1, and DUSP1 [PMC7516207]. In the context of periodontitis, LINC00616 has been found to be upregulated and its inhibition has shown promising therapeutic potential [PMC9276003]. It acts as a competing endogenous RNA (ceRNA) to promote ferroptosis of periodontal ligament stem cells (PDLSCs) through the miR-370/TFRC axis [PMC9276003]. Inhibition of LINC00616 has been shown to improve cell viability and reduce cell death in PDLSCs [PMC9276003]. The underlying molecular mechanisms of LINC00616 in PDLSCs are yet to be fully investigated [PMC9276003]. Bioinformatic analyses have identified miR-370 as a target miRNA of LINC00616 [PMC9276003]. Furthermore, LINC00616 has also been found to be significantly overexpressed in periodontal ligament tissues in patients with periodontitis compared with normal controls [PMC9276003]. Overall, LINC00616 is an upregulated lncRNA that plays a role in promoting ferroptosis and may have therapeutic potential for periodontitis. However, further research is needed to fully understand its molecular mechanisms and its potential as a therapeutic target.

Genome locations

Gene Ontology annotations

Sequence

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UGUGUUGCUCCUUGUGGCAGGUAUACUGUUCCAAUGCCCUGGGAUCUCUGUAGUGGUCGGUACUGUAUUGAUUAUAAAUGGUGAAGUCCUAGUAUCUUGCUAGAGUGAGCUGGCCAGGAUGGUGGAGCUCUACCACCAUUUCACAGGUUAUAGACAGGGGCCACCAGGUUUCAGGAAAGCAGCAAUGACCCCUCAGUAAUAGUUGGAAAGUGUGAUAUGACACUGAGCUUCACUGUGUUGGUGAAGAAGAGGUGAGGAAAAUAAAAGCUGCAGUUUGCCUCCACCUCUGAAGAAGCACAAUACACCUUUCUGGGUUACCAAUGGGAUACUUCCCAACAGCUUUGUCAUCACAUACAAUAUUCUCAAACAAGAUCUUAAUGGCAUCUACUUUCUCCAGGAACACAGCCCCUGACCUGUGUGUGUUUGCGUAGAGAAGGCAUGCUAUGUACCCCCUAGGAUAUGAAAGAGAGGAUCCAUUUGCUUCAAAGAGCCCAUCAGCAAGCUGUCCUUCCUGUUUUAUCACAAGAUUCCUGUAGCAGAUUGAGCUCUGGCAGUUGAUCUCAGUGGCUUGAUAGAGUGUCAUUAUAAAAACGCACCUGGAAGAUUCUGUGGAAAAGACAACCUCAGAAGACCAAGAGGCUGACUUUGCAAGAGAGAGUCCGUUUACCACUUAGAACCGUGAACACCACCCCCGCCCUCAUUUAUCUCCAGACUUGAACUAGUGGUUAAAUCCCAACAUGUCCCAGAGAAGUCAAAAGCAUUGUAAAAUCUGGGAAUCUGCCCACCACUCAAGCCUGGGAAAGCUGGCAGAGGAUGCACGUGUUUUACUCACCUGAGUGUUUACAAUGCUCGUGAGGUGCCUCCCUGAUAUUUUUAUAGCAGAAUGGAGAAACACAACCAAGGAGAUACACCUAAGUAACAACAGCAAUGAUGUCAAAAAGAGUGCCUGAAUACUUAGGGUGGAGGUCCUGGACAUGCAAACCCAAGCUUCCUCUUUGCUGUGGCCAGGAAUCUGCAGUGAUUGAGAGCACAGACUGUAUCUAAAAUUCCACCUUUCAAAGUUCAGCAUAUUACUUUUUUUUUUCUUACACCUAUAAGUACAGAGGAAUGAAGAAGGAAUAAACAGACCUUCUGGAUAAUUGCAUCAGCCUUCCCCACUAUUCCAAUGCCAUGCUAACAUUUCAAGUAAUGUCCCUUUUGUCUUGCUGAGAAAAAAUCAUUUCAUGAUUUAUUACACUGGAUUAAAGGCUAUGCACACUCUGGAGUUGGAACAUGACUGAAGGGCAAGCAAGCAUAAAGGAUAUCAGAAACAGUUGAUGUGUUUAAAUUUUUCUGAAUUUCUCAAGUAAACUUUUUAGAAAGUAGUCUGAAGAUAAAAUGGUUAUAUAAGUUACUUAAACUGUAGAUGAUGGCACCUUUAUCCCUAUAUAAUAAAAUUAAGAUAACUCUUCUGGGCACUUUAUUUGGAAUUAAUUAUUUAAUCCUCAUAACAACGCCAUGAAGAUCAUACUAUUACCAUCCAAAGUUUACUGAGGAAGAUACUGAGGCAAGAUUUACAAUCCAAAGCAGAGUGGGAGGAAGAGACCUACAAGACCAUGUUUCAUUGGAUAGCUUUGGAGUAAUAUCUAUAAUUUUAGAAAAAAGUUAAGAGGAAGAAGAAACUGGUGUCAGCUACACUUAGAAGAUUUUACAACAGAGACUGGCUUCCAUUCACUGAUCAGACAUUCACUGAUUUUUAAUUCUUACCACCAGAGAAAAAGUUGUUAUGAUGAGGGUCCUCAGGAAAGACAAUACAGUCAGCCGAGAAAUACAAUUUUCUUUGUCUACUGUUGUUUCCUUUACACGGACCAUUGAAAUAUAUACUUAACCACCAGCAAAACUCCUAUUAAACACAAGUAAAAAAAAAUCACUACAUGCAAAAGAGUGAACACCAGGCAAAGUGAUAAUUUAUGAAUUUCCAGGAUUUUUGUUGUAAUUUACCCGUGUAAGUUUACAAUAAAUGAUUGAUGUAACUAAA

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