gga-mir-19a: Gga-mir-19a is a microRNA that has been found to positively regulate the activity of the NF-κB signaling pathway in inflammation by inhibiting ZMYND11 expression [PMC5021716]. In a study conducted by GenePharma in Shanghai, China, a gga-mir-19a mimic (miR-19a) and an inhibitor (miR-19a-Inh) were designed and synthesized [PMC5021716]. These results provide evidence of the role of gga-mir-19a in modulating the NF-κB signaling pathway and its potential involvement in inflammation [PMC5021716]. The study suggests that gga-mir-19a acts as a positive regulator by inhibiting ZMYND11 expression, which is known to negatively regulate NF-κB activity [PMC5021716]. The design and synthesis of gga-mir-19a mimics and inhibitors by GenePharma provide valuable tools for further investigating the role of gga-mir-19a in inflammation and its potential as a therapeutic target [PMC5021716]. These findings contribute to our understanding of the complex regulatory mechanisms involved in NF-κB signaling and highlight the importance of microRNAs, such as gga-mir-19a, in modulating inflammatory responses [PMC5021716]. Further research is needed to elucidate the precise mechanisms through which gga-mir-19a regulates NF-kB signaling and its potential therapeutic applications.
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