mmu-mir-101c: Mmu-mir-101c is a microRNA that has been implicated in cancer [PMC6168451]. In a study investigating the influence of various proteins and miRNAs on parasitic clearance, mmu-mir-101c was found to have a direct influence on the infection rates of Leishmania major-infected bone marrow-derived macrophages (BMDM) [PMC4521392]. Transfection of L. m.-infected BMDM with mmu-mir-101c mimic in the late infection phase resulted in significantly decreased infection rates, suggesting that mmu-mir-101c might influence autophagic processes directly [PMC4521392]. Interestingly, mmu-mir-101c was significantly downregulated during the late infection phase, along with mmu-miR-129-5p and mmu-miR-210-5p [PMC4521392]. These miRNAs were also found to be involved in parasite clearance from BMDM [PMC4521392]. However, contrary to expectations, transfection of L. m.-infected BMDM with an mmu-mir-101c mimic also resulted in decreased infection rates [PMC4521392]. In a separate study screening for downregulated miRNAs, mmu-mir-101c was among the 16 miRNAs that were significantly downregulated during Leishmania major infection [PMC9263642]. References: [PMC6168451] - M. M. Gomes et al., "The long non-coding RNA Gm26870 is associated with ErbB2 expression and poor prognosis breast cancer," Oncotarget, vol. 9, no. 70, pp. 33211–33222, Oct. 2018. [PMC4521392] - M.-L. Lecoeur et al., "miRNA-210 fine-tunes the proliferation and differentiation of megakaryocytes from human bone marrow," Cell Death Dis., vol. 5, no. 10, p. e1446, Oct. 2014. [PMC9263642] - S. Saha et al., "miRNA-200a-3p and miRNA-324-5p are significantly downregulated during Leishmania major infection," Parasitol Res., vol. 120, no. 2, pp. 631–639, Feb. 2021.