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mmu-mir-322: Mmu-mir-322 is a microRNA that is upregulated in the thymus and is associated with the modulation of cellular metabolism [PMC9198802]. It has been found to be orthologous to human miR-424 and has been shown to protect hearts in mice from the effects of a high-fat diet [PMC5979329]. In various studies, expression levels of mmu-mir-322 have been evaluated, and it has been found that levels of miR-17, miR-21, and miR-223 were reduced while levels of mmu-mir-322 were increased [PMC4731388]. High expression of mmu-mir-322 has also been associated with cell differentiation, folliculogenesis, and ovarian development [PMC4499447]. On the other hand, down-regulation of mmu-mir-322 has been observed in the context of endoplasmic reticulum stress and the unfolded protein response [PMC6291480]. Computational target prediction analysis suggests that mmu-mir-322 does not directly bind to genes associated with Nox2 or its regulation [PMC6356993]. Mmu-mir-322 has also been found to be more prominent in regulatory networks and may play crucial roles in various biological processes [PMC3692539][PMC3767082][PMC5544724][PMC4069098][PMC3540168][PMC7386314]. It is highly expressed in placental tissue and its abundance can be quantified using qRT-PCR [PMC6366741]. In response to IFN-gamma treatment, mmu-miR-29a/b was downregulated while mmu-mir-322 was upregulated [PMC5543588].
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